DrugDashboards

Dihydroergotamine Mesylate

Dihydroergotamine Mesylate · DIHYDROERGOTAMINE MESYLATE 1 mg/mL · Injection, Solution · Intramuscular; Intravenous; Subcutaneous · Provepharm Inc.

NDC 81284-0411-05 · 5 AMPULE in 1 CARTON / 1 mL in 1 AMPULE · ANDA · View full market →

The short version

Just 3 companies supply this market — thin enough that a single exit would be felt immediately. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$52.64per MLinvoice-surveyed acquisition cost · Sep 18, 2024
  • Medicare Part B pays (ASP+6%)$54.98per billing unit (1 MG)HCPCS J1110 · Jul 1, 2026
  • Part D plans paid (avg)$149.46per dosage unitgross, before rebates — matched by drug name · 2024
  • Federal contracts pay (FSS)$335.84per package of 5X1MLAvKare, LLC · Jun 15, 2023

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

$0$20.00$40.00$60.00Apr 2024Sep 2024$52.64
7 price points · per ML · last surveyed Invalid DateSource: CMS NADAC

Estimated fill cost

WAC per package, as filed
$390.00
Reported to Texas DSHS · 2026 annual filing · Provepharm, Inc.

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicare Part B (ASP)

Payment limit per 1 MG
$54.978
HCPCS J1110 · Jul 1, 2026 quarter · typically ASP + 6%

Medicaid spend (2025)

$12,699
31 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

20Low risk

Some pressure is visible, but not much — here’s everything the score found to count.

  • 3 active manufacturers+10
  • sterile injectable+10

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

Is this a "specialty" drug?

There's no legal definition — it meets 2 of 6 public criteria. Why that matters →

  • Part D specialty tier
  • Costs ≥ $950/fill · avg $1,538.05 per prescription
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program

Regulatory

Application
ANDA212046
TE code
AP
Approval date
Jan 7, 2020
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

  • Class II · OngoingNov 22, 2024
    Provepharm Inc.Discoloration

Manufacturers of Dihydroergotamine Mesylate (Injection, Solution)

LabelerStrengthFirst seenLast seen
Baxter Healthcare CorporationDIHYDROERGOTAMINE MESYLATE 1 mg/mLJul 15, 2026Sep 2, 2026
Milla Pharmaceuticals Inc.DIHYDROERGOTAMINE MESYLATE 1 mg/mLJul 15, 2026Sep 2, 2026
Provepharm Inc.DIHYDROERGOTAMINE MESYLATE 1 mg/mLJul 15, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Dihydroergotamine Mesylate — NDC 81284-0411-05," retrieved September 3, 2026, https://drugdashboards.com/drug/81284041105.

Free to cite with attribution — see how the data is put together.