DrugDashboards

BiEST 5.0 Estrogen Cream

estriol,estradiol · ESTRIOL 4 mg/85g; ESTRADIOL 1 mg/85g · Cream · Transdermal · Shyne Brands

NDC 82018-0009-03 · 85 g in 1 BOTTLE, PUMP · UNAPPROVED DRUG OTHER · View full market →

The short version

Just 2 companies supply this market — thin enough that a single exit would be felt immediately.

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Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.

Supply fragility

Not scored — fragility is computed for NADAC-priced NDCs.

Regulatory

Application
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TE code
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Approval date
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Patents / exclusivity
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Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of estriol,estradiol (Cream)

LabelerStrengthFirst seenLast seen
Shyne BrandsESTRIOL 4 mg/85g; ESTRADIOL 1 mg/85gAug 26, 2026Sep 2, 2026
SHYNE BRANDS/BIOLabs PROESTRIOL 4 mg/102g; ESTRADIOL 1 mg/102gAug 26, 2026Sep 2, 2026
Shyne BrandsESTRIOL 1 mg/85g; ESTRADIOL 4 mg/85gJul 22, 2026Aug 19, 2026
SHYNE BRANDS/BIOLabs PROESTRIOL 1 mg/102g; ESTRADIOL 4 mg/102gJul 22, 2026Aug 19, 2026
Shyne BrandsESTRADIOL 1 mg/85g; ESTRIOL 4 mg/85gJul 15, 2026Jul 15, 2026
SHYNE BRANDS/BIOLabs PROESTRADIOL 1 mg/102g; ESTRIOL 4 mg/102gJul 15, 2026Jul 15, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "BiEST 5.0 Estrogen Cream — NDC 82018-0009-03," retrieved September 3, 2026, https://drugdashboards.com/drug/82018000903.

Free to cite with attribution — see how the data is put together.