The short version
6 companies supply this market — a reasonable cushion if one runs into trouble.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
FLO PMS Complete
Acetaminophen, Caffeine, Pyrilamine maleate · ACETAMINOPHEN 500 mg/1; CAFFEINE 60 mg/1; PYRILAMINE MALEATE 15 mg/1 · Tablet · Oral · O Positiv, Inc.
NDC 83049-0489-08 · 3 BLISTER PACK in 1 CARTON / 8 TABLET in 1 BLISTER PACK · OTC MONOGRAPH DRUG · View full market →
Medicare Part D
Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
Is this a "specialty" drug?
There's no legal definition — it meets 1 of 6 public criteria. Why that matters →
- Part D specialty tier
- Costs ≥ $950/fill
- Biologic (BLA)
- Injectable / infused
- Orphan-drug exclusivity
- REMS program · Opioid Analgesic REMS Shared System REMS
Regulatory
- Application
- M013
- TE code
- —
- Approval date
- —
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of Acetaminophen, Caffeine, Pyrilamine maleate (Tablet)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Bioventure Healthcare - FZE | ACETAMINOPHEN 500 mg/1; CAFFEINE 60 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| O Positiv, Inc. | ACETAMINOPHEN 500 mg/1; CAFFEINE 60 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Pioneer Life Sciences, LLC | CAFFEINE 60 mg/1; PYRILAMINE MALEATE 15 mg/1; ACETAMINOPHEN 500 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Strive Pharmaceuticals Inc. | ACETAMINOPHEN 500 mg/1; CAFFEINE 60 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Target | ACETAMINOPHEN 500 mg/1; CAFFEINE 60 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| JC World Bell Wholesale Co., Inc. | ACETAMINOPHEN 500 mg/1; CAFFEINE 60 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Aug 31, 2026 |
| Pioneer Life Sciences, LLC | CAFFEINE 500 mg/1; PYRILAMINE MALEATE 60 mg/1; ACETAMINOPHEN 15 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Pioneer Life Sciences, LLC | ACETAMINOPHEN 500 mg/1; CAFFEINE 60 mg/1; PYRILAMINE MALEATE 15 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "FLO PMS Complete — NDC 83049-0489-08," retrieved September 3, 2026, https://drugdashboards.com/drug/83049048908.
Free to cite with attribution — see how the data is put together.