The short version
Only one company currently supplies this market — there is no backup if it stumbles.
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456 Acne Relief Cream
Niacinamide,salicylic Acid,centella Asiatica Root,coptis Chinensis Root · SALICYLIC ACID 380 mg/50g; NIACINAMIDE 1000 mg/50g; COPTIS CHINENSIS ROOT 120 mg/50g; CENTELLA ASIATICA ROOT 100 mg/50g · Cream · Topical · Guangzhou Senmai Biotechnology Co.,Ltd.
NDC 84509-0111-01 · 50 g in 1 BOTTLE · OTC MONOGRAPH DRUG · View full market →
Medicare Part D
Medicare Part D does not cover over-the-counter drugs — by law it pays only for products requiring a prescription.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
Regulatory
- Application
- M016
- TE code
- —
- Approval date
- —
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of Niacinamide,salicylic Acid,centella Asiatica Root,coptis Chinensis Root (Cream)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Guangzhou Senmai Biotechnology Co.,Ltd. | NIACINAMIDE 400 mg/20g; COPTIS CHINENSIS ROOT 4 mg/20g; CENTELLA ASIATICA ROOT 48 mg/20g; SALICYLIC ACID 152 mg/20g | Aug 26, 2026 | Sep 2, 2026 |
| Guangzhou Senmai Biotechnology Co.,Ltd. | SALICYLIC ACID 380 mg/50g; NIACINAMIDE 1000 mg/50g; COPTIS CHINENSIS ROOT 120 mg/50g; CENTELLA ASIATICA ROOT 100 mg/50g | Aug 26, 2026 | Sep 2, 2026 |
| Guangzhou Senmai Biotechnology Co.,Ltd. | SALICYLIC ACID 100 mg/50g; NIACINAMIDE 120 mg/50g; COPTIS CHINENSIS ROOT 1000 mg/50g; CENTELLA ASIATICA ROOT 380 mg/50g | Aug 6, 2026 | Aug 20, 2026 |
| Guangzhou Senmai Biotechnology Co.,Ltd. | NIACINAMIDE 48 mg/20g; COPTIS CHINENSIS ROOT 4 mg/20g; CENTELLA ASIATICA ROOT 400 mg/20g; SALICYLIC ACID 152 mg/20g | Jul 22, 2026 | Aug 19, 2026 |
| Guangzhou Senmai Biotechnology Co.,Ltd. | CENTELLA ASIATICA ROOT 48 mg/20g; COPTIS CHINENSIS ROOT 4 mg/20g; NIACINAMIDE 400 mg/20g; SALICYLIC ACID 152 mg/20g | Jul 15, 2026 | Jul 15, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "456 Acne Relief Cream — NDC 84509-0111-01," retrieved September 3, 2026, https://drugdashboards.com/drug/84509011101.
Free to cite with attribution — see how the data is put together.