The short version
20 companies supply this market — deep enough that no single failure threatens the supply. The price has held steady around $0.0570 per gram over the past year.
Market view
diphenhydramine hydrochloride, zinc acetate · Cream
20 marketed package NDCs · 20 active manufacturers
Most dispensed: 2 g/100g; .1 g/100g · Cream · #1 tube/carton / 28 g in 1 tube · .1 g/100g; DIPHENHYDRAMINE HCL 2 g/100g · Cream · #1 tube/carton / 1 g in 1 tube
Price range and competition
RSS: changes for this drugEvery company selling this drug reports its own price. The line follows the middle of the pack; the shaded band holds the middle half of companies — the wider it is, the more they disagree.
Latest · Sep 2026 — typical price $0.057 · middle half $0.057–$0.057 · full range $0.057–$0.057 · 6 products · 20 companies
ⓘ How this was built
Data sources
- CMS NADAC weekly survey + monthly archives back to 2013 (data.medicaid.gov)
- CMS Federal Upper Limit files (weighted AMP)
- FDA NDC Directory (openFDA) — maker roster
Method
Each month's band spans the NADAC unit prices of every NDC of this drug (min, quartiles, median, max), split into brand and generic cohorts by FDA marketing category. Maker counts come from distinct labelers with the NDC actively listed.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
What changed in the last 90 days
Every detected change for diphenhydramine hydrochloride, zinc acetate, newest first — price moves, shortages, recalls, and manufacturers entering or leaving. Detected by comparing each day’s federal data against the day before.
- Itch StoppingSep 3, 2026Mfr enteredHyVee Inc · diphenhydramine hydrochloride, zinc acetate
- Itch StoppingSep 3, 2026New productHyVee Inc
- Anti-Itch CreamSep 2, 2026Mfr exitedKroger · diphenhydramine hydrochloride, zinc acetate
- GNP Extra Strength Anti-Itch CreamSep 2, 2026Mfr exitedAmerisource Bergen · diphenhydramine hydrochloride, zinc acetate
- Anti-Itch CreamAug 26, 2026Mfr enteredKroger · diphenhydramine hydrochloride, zinc acetate
- GNP Extra Strength Anti-Itch CreamAug 26, 2026Mfr enteredAmerisource Bergen · diphenhydramine hydrochloride, zinc acetate
- foster and thrive anti itch creamAug 19, 2026Price upNADAC $0.05672 → $0.05699 per unit (+0.48%)
- leader anti itchAug 19, 2026Price upNADAC $0.05672 → $0.05699 per unit (+0.48%)
- GNP Extra Strength Anti-Itch CreamAug 19, 2026Price upNADAC $0.05672 → $0.05699 per unit (+0.48%)
- diphenhydramine hcl and zinc acetateAug 19, 2026Price upNADAC $0.05672 → $0.05699 per unit (+0.48%)
Same drug class
Other molecules FDA puts in Copper Absorption Inhibitor, with whether each is in shortage right now. Same class is not the same drug — substitution is a clinical decision, and this is a supply picture, not a recommendation.
- .beta.-carotene, ascorbic acid, cholecalciferol, .alpha.-tocopherol acetate, dl-, thiamine mononitrate, riboflavin, niacinamide, pyridoxine hydrochloride, folic acid, levomefolate calcium, calcium formate, ferrous asparto glycinate, cyanocobalamin, biotin, potassium iodide, magnesium oxide, zinc oxide and cupric oxide· 1 maker
- .beta.-carotene, ascorbic acid, cholecalciferol, .alpha.-tocopherol acetate, dl-, thiamine, riboflavin, niacinamide, pyridoxine hydrochloride, folic acid, cyanocobalamin, calcium pantothenate, calcium carbonate, ferrous fumarate, zinc oxide and docusate sodium· 1 maker
- 2.75% octinsalate, 7.50% octinoxate, 8.00% zinc oxide sunscreen· 1 maker
- acetaldehyde, alfalfa, alpha-ketoglutaricum acidum, alpha-lipoicum acidum, ascorbyl palmitate, cobaltum metallicum, cysteinum, dimethyl glycine, ferrum metallicum, fucus vesiculosus, gaba (gamma aminobutyric acid), glutathione, hordeum vulgare, l-methionine, magnesium fluoratum, manganese gluconate, nasturtium aquaticum, oryza sativa, quercetin, raphanus sativus, selenium metallicum, sodium selenite, triticum aestivum, ubidecarenonum, vitamin e, zinc picolinate, zincum metallicum· 1 maker
- aceticum acidum, ammonium muriaticum, argentum metallicum, aurum metallicum, calcarea fluorica, calcarea phosphorica, carbolicum acidum, citrus limonum, cuprum metallicum, ferrum metallicum, glycyrrhiza glabra, lappa major, medulla ossis suis, mercurius solubilis, myrrha, natrum fluoratum, palladium metallicum, phosphoricum acidum, phytolacca decandra, selenium metallicum, silicea, stannum metallicum, staphysagria, stillingia sylvatica, trifolium pratense, x-ray, zincum oxydatum· 1 maker
- aconitum napellus root, onion, gelsemium sempervirens root, and zinc gluconate· 1 maker
- aconitum napellus, allium cepa, gelsemium semp., zincum gluconicum· 1 maker
- aconitum napellus, bryonia alba root, eupatorium perfoliatum flowering top, goldenseal, lachesis muta venom, phosphorus, vincetoxicum hirundinaria root, zinc gluconate, zinc acetate anhydrous, cairina moschata heart/liver autolysate, ipecac, sulfur· 1 maker
- aconitum napellus, bryonia alba, eupatorium perfoliatum, ferrum phosphoricum, gelsemium sempervirens, kali bichromicum, kali lodatum, zincum gluconicum.· 1 maker
- aconitum napellus, cairina moschata heart/liver autolysate, bryonia alba whole, eupatorium perfoliatum flowering top, ipecac, lachesis muta venom,phosphorus, pulsatilla vulgaris, sulfur, zinc gluconate, and zinc· 1 maker
- adenosinum cyclophosphoricum, adenosinum triphosphoricum dinatrum, alpha-ketoglutaricum acidum, berberis vulgaris, citricum acidum, coenzyme a, dna, fumaricum acidum, glycyrrhiza glabra, hepar sulphuris calcareum, lappa major, magnesia phosphorica, manganum aceticum, nadidum, natrum muriaticum, natrum oxalaceticum, natrum pyruvicum, nicotinamidum, pulsatilla, pyridoxinum hydrochloricum, rhamnus purshiana, riboflavinum, rna, silicea, succinicum acidum, sulphur, thiaminum hydrochloricum,· 1 maker
- agnus castus, arnica montana, arsenicum album, aurum muriaticum natronatum, avena sativa, baryta carbonica, caladium seguinum, calcarea carbonica, calcarea fluorica, calcarea phosphorica, calcarea sulphurica, glandula suprarenalis suis, hypophysis suis, hypothalamus suis, kali muriaticum, kali phosphoricum, lycopodium clavatum, magnesia phosphorica, manganum sulphuricum, natrum phosphoricum, natrum sulphuricum, nuphar luteum, orchitinum (suis), pancreas suis, ruta graveolens, sabal serrulata,· 1 maker
Common questions
- Is Diphenhydramine hydrochloride, zinc acetate in shortage right now?
- No. FDA does not currently list Diphenhydramine hydrochloride, zinc acetate in shortage. This page is rebuilt every morning from FDA's shortage database, so a new posting appears here the day it is published.
- Who makes Diphenhydramine hydrochloride, zinc acetate?
- 20 companies have marketed Diphenhydramine hydrochloride, zinc acetate in the last 30 days, according to the FDA NDC Directory. Every manufacturer and package is listed on this page.
- What does Diphenhydramine hydrochloride, zinc acetate cost?
- The typical pharmacy pays about $0.0570 per gram, based on the most recent CMS NADAC survey of actual acquisition costs. That is what the pharmacy pays for the drug itself — not the cash price, and not what an insurer is billed.
All marketed products
Expand a strength to see its dosage forms, then package sizes, then each manufacturer and NDC. Click an NDC for its full detail page.