7 companies supply this market — a reasonable cushion if one runs into trouble.The brand price is down 18% over the past year, to $386.20 per mL.Generic versions run $1.23 per mL — 314× cheaper.It is in shortage right now — FDA lists the reason as “other”.
Brand-name products only. Every company selling this drug reports its own price. The line follows the middle of the pack; the shaded band holds the middle half of companies — the wider it is, the more they disagree.
middle half of companies’ pricestypical (median) pricecompanies actively selling (bottom lane)Priced per mLⓘPrices are per milliliter (mL) of the finished product, not per package.Source: CMS NADAC
ⓘ How this was built
Data sources
CMS NADAC weekly survey + monthly archives back to 2013 (data.medicaid.gov)
CMS Federal Upper Limit files (weighted AMP)
FDA NDC Directory (openFDA) — maker roster
Method
Each month's band spans the NADAC unit prices of every NDC of this drug (min, quartiles, median, max), split into brand and generic cohorts by FDA marketing category. Maker counts come from distinct labelers with the NDC actively listed.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
What changed in the last 90 days
Every detected change for methotrexate, newest first — price moves, shortages, recalls, and manufacturers entering or leaving. Detected by comparing each day’s federal data against the day before.
Other molecules FDA puts in Folate Analog Metabolic Inhibitor, with whether each is in shortage right now. Same class is not the same drug — substitution is a clinical decision, and this is a supply picture, not a recommendation.
Yes. FDA currently lists Methotrexate in shortage. This page is rebuilt every morning from FDA's shortage database.
Who makes Methotrexate?
37 companies have marketed Methotrexate in the last 30 days, according to the FDA NDC Directory. Every manufacturer and package is listed on this page.
What does Methotrexate cost?
The typical pharmacy pays about $1.50 per mL, based on the most recent CMS NADAC survey of actual acquisition costs. That is what the pharmacy pays for the drug itself — not the cash price, and not what an insurer is billed.
Shortage reports for this molecule
In shortage now — Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 0703-3671-01)Mar 13, 2023
In shortage now — Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 0703-3675-01)Mar 13, 2023
In shortage now — Methotrexate Sodium Preservative Free, Injection, 25 mg/1 mL (NDC 0703-3678-01)Mar 13, 2023
In shortage now — Methotrexate Sodium, Injection, 1 g/40 mL (25 mg/mL) (NDC 61703-124-40)Mar 13, 2023
In shortage now — Methotrexate Sodium, Injection, 1 g/40 mL (25 mg/mL) (NDC 61703-408-25)Mar 13, 2023
In shortage now — Methotrexate Sodium, Injection, 1 g/40 mL (25 mg/mL) (NDC 61703-408-41)Mar 13, 2023
All marketed products
Expand a strength to see its dosage forms, then package sizes, then each manufacturer and NDC. Click an NDC for its full detail page.