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Market view

diphenhydramine hcl, zinc acetate · Spray

10 marketed package NDCs · 10 active manufacturers

Most dispensed: .1 g/100mL; DIPHENHYDRAMINE HYDROCHLORIDE 2 g/100mL · Spray · #59 mL/bottle, spray · DIPHENHYDRAMINE HYDROCHLORIDE 20 mg/mL; 1 mg/mL · Spray · #59 mL/bottle, spray

The short version

10 companies supply this market — deep enough that no single failure threatens the supply. The price is up 13% over the past year, to $0.0472 per mL.

Price range and competition

RSS: changes for this drug

Every company selling this drug reports its own price. The line follows the middle of the pack; the shaded band holds the middle half of companies — the wider it is, the more they disagree.

$0$0.02$0.04$0.06Jul 2020Sep 2026010companies actively selling

Latest · Sep 2026 — typical price $0.0472 · middle half $0.0472$0.0472 · full range $0.0472$0.0472 · 2 products · 10 companies

middle half of companies’ pricestypical (median) pricecompanies actively selling (bottom lane)Priced per mLSource: CMS NADAC
ⓘ How this was built
Data sources
  • CMS NADAC weekly survey + monthly archives back to 2013 (data.medicaid.gov)
  • CMS Federal Upper Limit files (weighted AMP)
  • FDA NDC Directory (openFDA) — maker roster
Method

Each month's band spans the NADAC unit prices of every NDC of this drug (min, quartiles, median, max), split into brand and generic cohorts by FDA marketing category. Maker counts come from distinct labelers with the NDC actively listed.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

What changed in the last 90 days

Every detected change for diphenhydramine hcl, zinc acetate, newest first — price moves, shortages, recalls, and manufacturers entering or leaving. Detected by comparing each day’s federal data against the day before.

  • Itch ReliefSep 2, 2026
    Mfr exited
    The Kroger Co. · diphenhydramine hcl, zinc acetate
  • Mfr exited
    Westlake HB Pharma LLC · diphenhydramine hcl, zinc acetate
  • Mfr exited
    Valu Merchandisers · diphenhydramine hcl, zinc acetate
  • CVS Itch ReliefSep 2, 2026
    Mfr exited
    Cvs · diphenhydramine hcl, zinc acetate
  • Mfr exited
    Chain Drug Marketing Association · diphenhydramine hcl, zinc acetate
  • Amerisourcebergen Drug Corporation · diphenhydramine hcl, zinc acetate
  • Itch ReliefSep 2, 2026
    Mfr exited
    Hy-Vee, Inc · diphenhydramine hcl, zinc acetate
  • Itch ReliefAug 26, 2026
    Mfr entered
    The Kroger Co. · diphenhydramine hcl, zinc acetate
  • Mfr entered
    Westlake HB Pharma LLC · diphenhydramine hcl, zinc acetate
  • Mfr entered
    Valu Merchandisers · diphenhydramine hcl, zinc acetate

Same drug class

Other molecules FDA puts in Copper Absorption Inhibitor, with whether each is in shortage right now. Same class is not the same drug — substitution is a clinical decision, and this is a supply picture, not a recommendation.

Common questions

Is Diphenhydramine hcl, zinc acetate in shortage right now?
No. FDA does not currently list Diphenhydramine hcl, zinc acetate in shortage. This page is rebuilt every morning from FDA's shortage database, so a new posting appears here the day it is published.
Who makes Diphenhydramine hcl, zinc acetate?
11 companies have marketed Diphenhydramine hcl, zinc acetate in the last 30 days, according to the FDA NDC Directory. Every manufacturer and package is listed on this page.
What does Diphenhydramine hcl, zinc acetate cost?
The typical pharmacy pays about $0.0472 per mL, based on the most recent CMS NADAC survey of actual acquisition costs. That is what the pharmacy pays for the drug itself — not the cash price, and not what an insurer is billed.

All marketed products

Expand a strength to see its dosage forms, then package sizes, then each manufacturer and NDC. Click an NDC for its full detail page.