The short version
18 companies supply this market — deep enough that no single failure threatens the supply. The generic price is down 16% over the past year, to $0.0766 per unit. The brand runs $1.42 per unit — 19× more.
Market view
carbidopa and levodopa · Tablet
177 marketed package NDCs · 18 active manufacturers
Most dispensed: 25 mg; 100 mg · Tablet · #100 tablets/bottle · 10 mg; 100 mg · Tablet · #100 tablets/bottle · 25 mg; 250 mg · Tablet · #100 tablets/bottle · 25 mg; 100 mg · Tablet · #500 tablets/bottle
Price range and competition
RSS: changes for this drugpriced separately — they are not the same market
Generic products only. Every company selling this drug reports its own price. The line follows the middle of the pack; the shaded band holds the middle half of companies — the wider it is, the more they disagree.
Latest · Sep 2026 — typical price $0.0766 · middle half $0.0721–$0.1094 · full range $0.0675–$0.1094 · 63 products · 26 companies
ⓘ How this was built
Data sources
- CMS NADAC weekly survey + monthly archives back to 2013 (data.medicaid.gov)
- CMS Federal Upper Limit files (weighted AMP)
- FDA NDC Directory (openFDA) — maker roster
Method
Each month's band spans the NADAC unit prices of every NDC of this drug (min, quartiles, median, max), split into brand and generic cohorts by FDA marketing category. Maker counts come from distinct labelers with the NDC actively listed.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
What changed in the last 90 days
Every detected change for carbidopa and levodopa, newest first — price moves, shortages, recalls, and manufacturers entering or leaving. Detected by comparing each day’s federal data against the day before.
- Carbidopa and LevodopaSep 2, 2026Mfr exitedMayne Pharma International Pty Ltd · carbidopa and levodopa
- SinemetSep 2, 2026Mfr exitedOrganon LLC · carbidopa and levodopa
- DuopaSep 2, 2026Mfr exitedAbbVie Inc. · carbidopa and levodopa
- RytarySep 2, 2026Mfr exitedAmneal Pharmaceuticals LLC · carbidopa and levodopa
- RytarySep 2, 2026Mfr exitedAmneal Pharmaceuticals LLC · carbidopa and levodopa
- RytarySep 2, 2026Mfr exitedAmneal Pharmaceuticals LLC · carbidopa and levodopa
- RytarySep 2, 2026Mfr exitedAmneal Pharmaceuticals LLC · carbidopa and levodopa
- DuopaAug 26, 2026Mfr enteredAbbVie Inc. · carbidopa and levodopa
- RytaryAug 26, 2026Mfr enteredAmneal Pharmaceuticals LLC · carbidopa and levodopa
- RytaryAug 26, 2026Mfr enteredAmneal Pharmaceuticals LLC · carbidopa and levodopa
Same drug class
Other molecules FDA puts in Aromatic Amino Acid, with whether each is in shortage right now. Same class is not the same drug — substitution is a clinical decision, and this is a supply picture, not a recommendation.
- 5-methoxytryptamine, acetylcholine chloride, dopamine hydrochloride, gaba (gamma-aminobutyric acid), histaminum hydrochloricum, l-dopa, melatonin, norepinephrine (bitartrate), phenethylamine (hydrochloride), serotonin (hydrochloride), taurine, tyramine· 1 maker
- adenosinum cyclophosphoricum, petroselinum sativum, melatonin, pineal gland (suis), thalamus opticus (suis), l-dopa, viscum album, apiolum· 1 maker
- agaricus muscarius, aspartame, bufo rana, carcinosin, cerebrum suis, ethylicum, helleborus niger, hydrogen, hyoscyamus niger, kali bromatum, l-dopa, neon, olibanum (boswellia serrata), placenta totalis suis, serotonin (hydrochloride), stramonium, thuja occidentalis· 1 maker
- agnus castus, ambra grisea, estradiol, l-dopa, melatonin, petroselinum sativum, adenosinum triphosphoricum dinatrum, alpha-lipoicum acidum, nadidum, pantothenic acid, sarcolacticum acidum, ubidecarenonum, baryta carbonica, conium maculatum, selenium metallicum, folliculinum, testosterone, funiculus umbilicalis suis, glandula suprarenalis suis, hepar suis, hypothalamus suis, lymph node (suis), medulla ossis suis, oophorinum (suis), orchitinum (suis), pancreas suis, spleen (suis), human growth hormone,· 1 maker
- agnus castus, ambra grisea, estradiol, l-dopa, melatonin, petroselinum sativum, adenosinum triphosphoricum dinatrum, alpha-lipoicum acidum, nadidum, pantothenic acid, sarcolacticum acidum, ubidecarenonum, baryta carbonica, conium maculatum, selenium metallicum, folliculinum, testosterone, funiculus umbilicalis suis, glandula suprarenalis suis, hepar suis, hypothalamus suis, lymph node (suis), medulla ossis suis, oophorinum (suis), orchitinum (suis), pancreas suis, spleen (suis), proteus (morgani)· 1 maker
- agnus castus, ambra grisea, petroselinum sativum, estradiol, l-dopa, melatonin, testosterone, adenosinum triphosphoricum dinatrum, alpha-lipoicum acidum, nadidum, pantothenic acid, sarcolacticum acidum, ubidecarenonum, baryta carbonica, conium maculatum, selenium metallicum, folliculinum, funiculus umbilicalis suis, gaba, glandula suprarenalis suis, hepar suis, hypothalamus suis, lymph node (suis), medulla ossis suis, oophorinum (suis), orchitinum (suis), pancreas suis, spleen (suis), apiolum,· 1 maker
- carbidopa levodopa· 1 maker
- carbidopa, levodopa, and entacapone· 1 maker
- ethylicum, kali bromatum, aspartame, l-dopa, serotonin (hydrochloride), cerebrum suis, placenta totalis suis, agaricus muscarius, bufo rana, helleborus niger, hyoscyamus niger, olibanum (boswellia serrata), stramonium, thuja occidentalis, helium, neon, carcinosin, hydrogen· 1 maker
- ethylicum, kali bromatum, aspartic acid, l-dopa, serotonin (hydrochloride), cerebrum suis, placenta totalis suis, agaricus muscarius, bufo rana, helleborus niger, hyoscyamus niger, olibanum (boswellia serrata), stramonium, thuja occidentalis, helium, neon, carcinosin, hydrogen· 1 maker
- gaba (gamma-aminobutyric acid), l-dopa, norepinephrine (bitartrate), serotonin (hydrochloride), adrenocorticotrophin, anacardium orientale, arsenicum album, baryta carbonica, calcarea carbonica, calcarea phosphorica, hyoscyamus niger, lycopodium clavatum, stramonium· 1 maker
- gaba, l-dopa, norepinephrine, serotonin, adrenocorticotrophin, anacardium orientale, arsenicum album, baryta carbonica, calcarea carbonica, calcarea phosphorica, hyoscyamus niger, lycopodium clavatum, stramonium· 1 maker
Common questions
- Is Carbidopa and levodopa in shortage right now?
- No. FDA does not currently list Carbidopa and levodopa in shortage. This page is rebuilt every morning from FDA's shortage database, so a new posting appears here the day it is published.
- Who makes Carbidopa and levodopa?
- 39 companies have marketed Carbidopa and levodopa in the last 30 days, according to the FDA NDC Directory. Every manufacturer and package is listed on this page.
- What does Carbidopa and levodopa cost?
- The typical pharmacy pays about $0.1094 per unit, based on the most recent CMS NADAC survey of actual acquisition costs. That is what the pharmacy pays for the drug itself — not the cash price, and not what an insurer is billed.
All marketed products
Expand a strength to see its dosage forms, then package sizes, then each manufacturer and NDC. Click an NDC for its full detail page.