The short version
24 companies supply this market — deep enough that no single failure threatens the supply. The price has jumped 64% in a year, to $2.16 per mL — sharp rises like this often mean supply is already tightening.
Market view
acetylcysteine
56 marketed package NDCs · 24 active manufacturers
Most dispensed: 200 mg/mL · Solution · #25 vials/carton / 4 ml in 1 vial · 200 mg/mL · Solution · #3 vials/carton / 30 ml in 1 vial · 100 mg/mL · Solution · #25 vials/carton / 4 ml in 1 vial · 100 mg/mL · Solution · #3 vials/carton / 30 ml in 1 vial
Price range and competition
RSS: changes for this drugEvery company selling this drug reports its own price. The line follows the middle of the pack; the shaded band holds the middle half of companies — the wider it is, the more they disagree.
Latest · Sep 2026 — typical price $2.16 · middle half $0.7413–$2.28 · full range $0.6351–$2.62 · 16 products · 24 companies
ⓘ How this was built
Data sources
- CMS NADAC weekly survey + monthly archives back to 2013 (data.medicaid.gov)
- CMS Federal Upper Limit files (weighted AMP)
- FDA NDC Directory (openFDA) — maker roster
Method
Each month's band spans the NADAC unit prices of every NDC of this drug (min, quartiles, median, max), split into brand and generic cohorts by FDA marketing category. Maker counts come from distinct labelers with the NDC actively listed.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
What changed in the last 90 days
Every detected change for acetylcysteine, newest first — price moves, shortages, recalls, and manufacturers entering or leaving. Detected by comparing each day’s federal data against the day before.
- AcetylcysteineAug 19, 2026Price downNADAC $0.74471 → $0.74133 per unit (-0.45%)
- AcetylcysteineAug 19, 2026Price downNADAC $2.23029 → $2.16334 per unit (-3%)
- AcetylcysteineAug 19, 2026Price downNADAC $2.6433 → $2.61887 per unit (-0.92%)
- AcetylcysteineAug 19, 2026Price downNADAC $2.6433 → $2.61887 per unit (-0.92%)
- AcetylcysteineAug 19, 2026Price downNADAC $2.23029 → $2.16334 per unit (-3%)
- AcetylcysteineAug 19, 2026Price downNADAC $2.23029 → $2.16334 per unit (-3%)
- AcetylcysteineAug 19, 2026Price downNADAC $0.63693 → $0.63509 per unit (-0.29%)
- AcetylcysteineAug 19, 2026Price downNADAC $0.74471 → $0.74133 per unit (-0.45%)
- AcetylcysteineAug 19, 2026Price downNADAC $0.74471 → $0.74133 per unit (-0.45%)
- AcetylcysteineAug 19, 2026Price downNADAC $2.23029 → $2.16334 per unit (-3%)
Same drug class
Other molecules FDA puts in Antidote for Acetaminophen Overdose, with whether each is in shortage right now. Same class is not the same drug — substitution is a clinical decision, and this is a supply picture, not a recommendation.
- acetylcysteine - ballota foetida - epinephrine - glutathione - interferon gamma-1b - lenograstim - lithium carbonate - melatonin - penicillium glabrum - potassium carbonate - pummelo - rhodotorula rubra - silver nitrate - strychnos nux-vomica seed - sus scrofa cerebral cortex - sus scrofa stomach - sus scrofa superior gastric plexus - sus scrofa thalamus -· 1 maker
- multivitamin· 2 makers
Common questions
- Is Acetylcysteine in shortage right now?
- No. FDA does not currently list Acetylcysteine in shortage. This page is rebuilt every morning from FDA's shortage database, so a new posting appears here the day it is published.
- Who makes Acetylcysteine?
- 24 companies have marketed Acetylcysteine in the last 30 days, according to the FDA NDC Directory. Every manufacturer and package is listed on this page.
- What does Acetylcysteine cost?
- The typical pharmacy pays about $2.16 per mL, based on the most recent CMS NADAC survey of actual acquisition costs. That is what the pharmacy pays for the drug itself — not the cash price, and not what an insurer is billed.
All marketed products
Expand a strength to see its dosage forms, then package sizes, then each manufacturer and NDC. Click an NDC for its full detail page.