The short version
Just 3 companies supply this market — thin enough that a single exit would be felt immediately. The brand price has held steady around $22.74 per gram over the past year.
Market view
fluticasone propionate and salmeterol xinafoate
11 marketed package NDCs · 3 active manufacturers
Most dispensed: 115 ug; 21 ug · Aerosol, Metered · #1 inhaler/carton / 120 aerosol, metered in 1 inhaler · 45 ug; 21 ug · Aerosol, Metered · #1 inhaler/carton / 120 aerosol, metered in 1 inhaler · 230 ug; 21 ug · Aerosol, Metered · #1 inhaler/carton / 120 aerosol, metered in 1 inhaler · 45 ug; 21 ug · Aerosol, Metered · #1 inhaler/carton / 60 aerosol, metered in 1 inhaler
Price range and competition
RSS: changes for this drugpriced separately — they are not the same market
Brand-name products only. Every company selling this drug reports its own price. The line follows the middle of the pack; the shaded band holds the middle half of companies — the wider it is, the more they disagree.
Latest · Sep 2026 — typical price $22.74 · middle half $20.00–$29.31 · full range $18.78–$35.02 · 6 products · 3 companies
ⓘ How this was built
Data sources
- CMS NADAC weekly survey + monthly archives back to 2013 (data.medicaid.gov)
- CMS Federal Upper Limit files (weighted AMP)
- FDA NDC Directory (openFDA) — maker roster
Method
Each month's band spans the NADAC unit prices of every NDC of this drug (min, quartiles, median, max), split into brand and generic cohorts by FDA marketing category. Maker counts come from distinct labelers with the NDC actively listed.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
What changed in the last 90 days
Every detected change for fluticasone propionate and salmeterol xinafoate, newest first — price moves, shortages, recalls, and manufacturers entering or leaving. Detected by comparing each day’s federal data against the day before.
- Fluticasone Propionate and Salmeterol HFAAug 19, 2026Price downNADAC $27.16506 → $27.07693 per unit (-0.32%)
- Fluticasone Propionate and Salmeterol HFAAug 19, 2026Price upNADAC $20.86859 → $20.96915 per unit (+0.48%)
- Fluticasone Propionate and Salmeterol HFAAug 19, 2026Price downNADAC $16.97393 → $16.85336 per unit (-0.71%)
- Advair HfaAug 19, 2026Price downNADAC $30.63688 → $30.607 per unit (-0.1%)
- Advair HfaAug 19, 2026Price downNADAC $35.02673 → $35.02332 per unit (-0.01%)
- Advair HfaAug 19, 2026Price upNADAC $18.74641 → $18.77945 per unit (+0.18%)
- Advair HfaAug 19, 2026Price upNADAC $25.40129 → $25.41574 per unit (+0.06%)
- Advair HfaAug 19, 2026Price upNADAC $19.97353 → $19.97487 per unit (+0.01%)
- Advair HfaJul 29, 2026New shortageby this manufacturerGlaxoSmithKline's Advair Hfa (Aerosol, Metered, 115 ug; 21 ug) is newly in shortage3 companies market advair hfa
- Advair HfaJul 29, 2026New shortageby this manufacturerGlaxoSmithKline's Advair Hfa (Aerosol, Metered, 230 ug; 21 ug) is newly in shortage3 companies market advair hfa
Same drug class
Other molecules FDA puts in Corticosteroid, with whether each is in shortage right now. Same class is not the same drug — substitution is a clinical decision, and this is a supply picture, not a recommendation.
- triamcinolone hexacetonide· in shortage
- methylprednisolone acetate· in shortage
- methylprednisolone· in shortage
- dexamethasone sodium phosphate· in shortage
- dexamethasone· in shortage
- 1.85% hydrocortisone acetate - 1.15% pramoxine hci cream· 1 maker
- 1% hydrocortisone anti-itch· 1 maker
- acetaldehyde, aceticum ac, arg nit, caffeinum, calc sulph, citricum ac, cortisone aceticum, echinacea purp, folliculinum, fragaria, fumaricum ac, gallicum ac, glandula suprarenalis suis, hepar suis, histaminum hydrochloricum, hydrangea, lac vac, lecithin, limulus, lycopersicum, lycopodium, nat bicarb, nat mur, nux vom, paraffinum, phosphoricum ac, saccharum off, silicea, tartaricum ac, torula cerevisiae.· 1 maker
- acetaldehyde, dopamine hydrochloride, dhea (dehydroepiandrosterone), 7-oxo-dehydroepiandrosterone-3b-acetate, folliculinum, oophorinum (suis), cholesterinum, progesterone, testosterone, cortisone aceticum, aldosterone, androsterone, follicle stimulating hormone· 1 maker
- aceticum ac, acetylsal ac, adrenocorticotrophin, alumina, arsenicum alb, borago, ceanothus, chelidonium maj, chionanthus, chloramphenicolum, chlorpromazinum, cholesterinum, cortisone aceticum, damiana, folliculinum, fumaricum ac, kali iod, lycopodium, nat sulphuricum, nux vom, oleum morrhuae, petroleum, phenacetinum, phosphoricum ac, phosphorus, plumb met, saccharum off, silicea, taraxacum, thyroidinum.· 1 maker
- aceticum acidum, cacao, magnesia sulphurica, natrum sulphuricum, verbascum thapsus, glandula suprarenalis suis, pancreas suis, cortisone aceticum, thyroidinum (suis), iodium, lycopodium clavatum, phosphorus, ranunculus bulbosus, saccharum officinale, vanadium metallicum, zincum metallicum, chromium acidum, culex musca· 1 maker
- aconitum napellus, adrenalinum, ambra grisea, aurum muriaticum natronatum, calcarea sulphurica, cimicifuga racemosa, cinchona officinalis, cortisone aceticum, crocus sativus, dna, hyoscyamus niger, hypophysis suis, hypothalamus suis, ignatia amara, kali bromatum, lachesis mutus, pulsatilla (pratensis), thyroidinum (bovine), viola odorata· 1 maker
Common questions
- Is Fluticasone propionate and salmeterol xinafoate in shortage right now?
- No. FDA does not currently list Fluticasone propionate and salmeterol xinafoate in shortage. This page is rebuilt every morning from FDA's shortage database, so a new posting appears here the day it is published.
- Who makes Fluticasone propionate and salmeterol xinafoate?
- 3 companies have marketed Fluticasone propionate and salmeterol xinafoate in the last 30 days, according to the FDA NDC Directory. That is a thin market — if one stops making it, supply is at risk quickly. Every manufacturer and package is listed on this page.
- What does Fluticasone propionate and salmeterol xinafoate cost?
- The typical pharmacy pays about $20.97 per gram, based on the most recent CMS NADAC survey of actual acquisition costs. That is what the pharmacy pays for the drug itself — not the cash price, and not what an insurer is billed.
Shortage reports for this molecule
- Planned discontinuation — Advair HFA, Aerosol, Metered, 115 ug; 21 ug (NDC 0173-0716-22)Jul 27, 2026
- Planned discontinuation — Advair HFA, Aerosol, Metered, 230 ug; 21 ug (NDC 0173-0717-22)Jul 27, 2026
- Planned discontinuation — Advair HFA, Aerosol, Metered, 45 ug; 21 ug (NDC 0173-0715-22)Jul 27, 2026
All marketed products
Expand a strength to see its dosage forms, then package sizes, then each manufacturer and NDC. Click an NDC for its full detail page.