DrugDashboards

Diphenhydramine Hydrochloride

Diphenhydramine Hydrochloride · DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/10mL · Solution · Oral · PAI Holdings, LLC dba PAI Pharma

NDC 00121-0978-00 · 10 TRAY in 1 CASE / 10 CUP, UNIT-DOSE in 1 TRAY / 10 mL in 1 CUP, UNIT-DOSE · ANDA · View full market →

The short version

26 companies supply this market — deep enough that no single failure threatens the supply.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Federal contracts pay (FSS)$408.33per package of 100X0MLGolden State Medical Supply, Inc. · Jul 4, 2025
  • List price (WAC, as filed)$375.95per packagePharmaceutical Associates, Inc. · Mar 15, 2022

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.

Estimated fill cost

WAC per package, as filed
$413.17
Reported to Texas DSHS · 2026 annual filing · PAI Holdings LLC dba Pharmaceutical Associates, Inc. / PAI Pharma

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicaid spend (2025)

$20,021
1,785 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

Not scored — fragility is computed for NADAC-priced NDCs.

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for diphenhydramine hydrochloride (other) in the next 90 days

sole-source market · price up 9% YoY

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Regulatory

Application
ANDA087513
TE code
AA
Approval date
Feb 10, 1982
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

  • Class II · TerminatedApr 13, 2022
    Mckesson Medical-Surgical Inc. Corporate Office — cGMP deviations: Temperature abuse

Manufacturers of Diphenhydramine Hydrochloride (Solution)

LabelerStrengthFirst seenLast seen
Kenvue Brands LLCDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 3, 2026
PAI Holdings, LLC dba PAI PharmaDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 3, 2026
PAI Holdings, LLC dba PAI PharmaDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/10mLJul 15, 2026Sep 3, 2026
American Health PackagingDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/10mLJul 15, 2026Sep 2, 2026
American Health PackagingDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Amerisource BergenDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Camber Pharmaceuticals, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Camber Pharmaceuticals, Inc.DIPHENHYDRAMINE HYDROCHLORIDE 25 mg/10mLJul 15, 2026Sep 2, 2026
Dolgencorp, LLCDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Foundation Consumer HealthcareDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/10mLJul 15, 2026Sep 2, 2026
Kroger CompanyDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Major PharmaceuticalsDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Major PharmaceuticalsDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/10mLJul 15, 2026Sep 2, 2026
Medical Purchasing Solutions, LLCDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/10mLJul 15, 2026Sep 2, 2026
Meijer Distribution IncDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Meijer Distribution IncDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/30mLJul 15, 2026Sep 2, 2026
Natco Pharma USA LLCDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Natco Pharma USA LLCDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/10mLJul 15, 2026Sep 2, 2026
Oncor PharmaceuticalsDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Preferred Pharmaceuticals Inc.DIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Proficient Rx LPDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Quality Choice (Chain Drug Marketing Association)DIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Redmont Pharmaceuticals, LLCDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLAug 5, 2026Sep 2, 2026
Strategic Sourcing Services LLCDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Target CorporationDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/30mLJul 15, 2026Sep 2, 2026
Topco Associates LLCDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Wal-Mart Stores IncDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Wal-Mart Stores Inc.DIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Walgreen CompanyDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026
Walgreen CompanyDIPHENHYDRAMINE HYDROCHLORIDE 50 mg/30mLJul 15, 2026Sep 2, 2026
Walgreen CompanyDIPHENHYDRAMINE HYDROCHLORIDE 25 mg/10mLJul 15, 2026Sep 2, 2026
Winco Foods, LlcDIPHENHYDRAMINE HYDROCHLORIDE 12.5 mg/5mLJul 15, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Diphenhydramine Hydrochloride — NDC 00121-0978-00," retrieved September 3, 2026, https://drugdashboards.com/drug/00121097800.

Free to cite with attribution — see how the data is put together.