DrugDashboards

Naproxen and esomeprazole magnesium

Naproxen and esomeprazole magnesium · NAPROXEN 375 mg/1; ESOMEPRAZOLE MAGNESIUM 20 mg/1 · Tablet, Delayed Release · Oral · Ajanta Pharma USA Inc.

NDC 27241-0202-60 · 60 TABLET, DELAYED RELEASE in 1 BOTTLE · ANDA · View full market →

The short version

11 companies supply this market — deep enough that no single failure threatens the supply. The price has fallen 32% in a year, to $2.90 per unit — and generics that get this cheap tend to get abandoned rather than defended. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$2.90per EAinvoice-surveyed acquisition cost · Jul 22, 2026
  • Medicaid generic ceiling (FUL)$2.90per TABweighted avg manufacturer price $0.9947 · Aug 1, 2026100% of what pharmacies pay — higher than 10% of drugs with this benchmark

Medicare Part D

All Part D pricing →

Matched to CMS's representative package for this drug (NDC 55111-0289-60) — same generic, strength, and dosage form. CMS prices one NDC per drug concept, not every package.

ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$9.48per unit
middle half $8.18$9.48 · 27 plans · Apr 1, 2026
Est. net of rebates
≈ $9.48
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
0%of plans cover it
tier 4 · prior auth 100% · step therapy 0% · qty limit 100%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.

NADAC price per unit

$0$2.00$4.00$6.00Apr 2024Sep 2026$2.90
25 price points · per EA · held since Invalid Date · dashed = manufacturer avg (WAMP)Source: CMS NADAC

Estimated fill cost

#30 count
$86.97
#90 count
$260.91

Estimates: latest NADAC unit price × quantity. Pharmacy acquisition cost only — excludes dispensing fees, markup, and insurance terms.

Medicaid spend (2025)

$108,535
328 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

8Low risk

Some pressure is visible, but not much — here’s everything the score found to count.

  • price down 32% year over year+8

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for naproxen and esomeprazole magnesium (oral solid) in the next 90 days

sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Regulatory

Application
ANDA213699
TE code
AB
Approval date
Oct 6, 2022
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Naproxen and esomeprazole magnesium (Tablet, Delayed Release)

LabelerStrengthFirst seenLast seen
Bryant Ranch PrepackNAPROXEN 500 mg/1; ESOMEPRAZOLE MAGNESIUM 20 mg/1Aug 26, 2026Sep 3, 2026
Ajanta Pharma USA Inc.NAPROXEN 500 mg/1; ESOMEPRAZOLE MAGNESIUM 20 mg/1Aug 26, 2026Sep 2, 2026
Ajanta Pharma USA Inc.NAPROXEN 375 mg/1; ESOMEPRAZOLE MAGNESIUM 20 mg/1Aug 26, 2026Sep 2, 2026
Asclemed USA, Inc.NAPROXEN 500 mg/1; ESOMEPRAZOLE MAGNESIUM 20 mg/1Aug 26, 2026Sep 2, 2026
Asclemed USA, Inc.NAPROXEN 375 mg/1; ESOMEPRAZOLE MAGNESIUM 20 mg/1Aug 26, 2026Sep 2, 2026
Doc RxNAPROXEN 500 mg/1; ESOMEPRAZOLE MAGNESIUM 20 mg/1Aug 26, 2026Sep 2, 2026
Dr. Reddy's Laboratories LimitedNAPROXEN 500 mg/1; ESOMEPRAZOLE MAGNESIUM 20 mg/1Aug 26, 2026Sep 2, 2026
Dr. Reddy's Laboratories LimitedNAPROXEN 375 mg/1; ESOMEPRAZOLE MAGNESIUM 20 mg/1Aug 26, 2026Sep 2, 2026
Patheon Pharmaceuticals Inc.ESOMEPRAZOLE MAGNESIUM 20 mg/1; NAPROXEN 500 mg/1Jul 15, 2026Sep 2, 2026
Patheon Pharmaceuticals Inc.ESOMEPRAZOLE MAGNESIUM 20 mg/1; NAPROXEN 375 mg/1Jul 15, 2026Sep 2, 2026
Phoenix Rx LlcNAPROXEN 375 mg/1; ESOMEPRAZOLE MAGNESIUM 20 mg/1Aug 26, 2026Sep 2, 2026
Preferred Pharmaceuticals IncNAPROXEN 375 mg/1; ESOMEPRAZOLE MAGNESIUM TRIHYDRATE 20 mg/1Aug 26, 2026Sep 2, 2026
Preferred Pharmaceuticals Inc.NAPROXEN 375 mg/1; ESOMEPRAZOLE MAGNESIUM TRIHYDRATE 20 mg/1Aug 26, 2026Sep 2, 2026
Proficient Rx LPNAPROXEN 500 mg/1; ESOMEPRAZOLE MAGNESIUM TRIHYDRATE 20 mg/1Aug 26, 2026Sep 2, 2026
ScieGen Pharmaceuticals, IncNAPROXEN 500 mg/1; ESOMEPRAZOLE MAGNESIUM 20 mg/1Aug 26, 2026Sep 2, 2026
ScieGen Pharmaceuticals, IncNAPROXEN 375 mg/1; ESOMEPRAZOLE MAGNESIUM 20 mg/1Aug 26, 2026Sep 2, 2026
Phoenix Rx LlcNAPROXEN 500 mg/1; ESOMEPRAZOLE MAGNESIUM 20 mg/1Aug 26, 2026Aug 28, 2026
Preferred Pharmaceuticals Inc.NAPROXEN 500 mg/1; ESOMEPRAZOLE MAGNESIUM TRIHYDRATE 20 mg/1Aug 26, 2026Aug 28, 2026
Bryant Ranch PrepackNAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM 500 mg/1Jul 22, 2026Aug 22, 2026
Phoenix Rx LlcNAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM 500 mg/1Jul 22, 2026Aug 22, 2026
Preferred Pharmaceuticals Inc.NAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM TRIHYDRATE 500 mg/1Jul 22, 2026Aug 22, 2026
Preferred Pharmaceuticals Inc.NAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM TRIHYDRATE 375 mg/1Jul 25, 2026Aug 22, 2026
Proficient Rx LPNAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM TRIHYDRATE 500 mg/1Jul 22, 2026Aug 22, 2026
Ajanta Pharma USA Inc.NAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM 500 mg/1Jul 22, 2026Aug 19, 2026
Ajanta Pharma USA Inc.NAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM 375 mg/1Jul 22, 2026Aug 19, 2026
Asclemed USA, Inc.NAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM 375 mg/1Jul 22, 2026Aug 19, 2026
Asclemed USA, Inc.NAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM 500 mg/1Jul 22, 2026Aug 19, 2026
Doc RxNAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM 500 mg/1Jul 22, 2026Aug 19, 2026
Dr. Reddy's Laboratories LimitedNAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM 375 mg/1Jul 22, 2026Aug 19, 2026
Dr. Reddy's Laboratories LimitedNAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM 500 mg/1Jul 22, 2026Aug 19, 2026
Phoenix Rx LlcNAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM 375 mg/1Jul 22, 2026Aug 19, 2026
Preferred Pharmaceuticals IncNAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM TRIHYDRATE 375 mg/1Jul 22, 2026Aug 19, 2026
ScieGen Pharmaceuticals, IncNAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM 375 mg/1Jul 22, 2026Aug 19, 2026
ScieGen Pharmaceuticals, IncNAPROXEN 20 mg/1; ESOMEPRAZOLE MAGNESIUM 500 mg/1Jul 22, 2026Aug 19, 2026
Bryant Ranch PrepackESOMEPRAZOLE MAGNESIUM 20 mg/1; NAPROXEN 500 mg/1Jul 15, 2026Jul 19, 2026
Preferred Pharmaceuticals Inc.ESOMEPRAZOLE MAGNESIUM TRIHYDRATE 20 mg/1; NAPROXEN 500 mg/1Jul 15, 2026Jul 19, 2026
Phoenix Rx LlcESOMEPRAZOLE MAGNESIUM 20 mg/1; NAPROXEN 500 mg/1Jul 15, 2026Jul 18, 2026
Ajanta Pharma USA Inc.ESOMEPRAZOLE MAGNESIUM 20 mg/1; NAPROXEN 500 mg/1Jul 15, 2026Jul 15, 2026
Ajanta Pharma USA Inc.ESOMEPRAZOLE MAGNESIUM 20 mg/1; NAPROXEN 375 mg/1Jul 15, 2026Jul 15, 2026
Asclemed USA, Inc.ESOMEPRAZOLE MAGNESIUM 20 mg/1; NAPROXEN 375 mg/1Jul 15, 2026Jul 15, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Naproxen and esomeprazole magnesium — NDC 27241-0202-60," retrieved September 3, 2026, https://drugdashboards.com/drug/27241020260.

Free to cite with attribution — see how the data is put together.