The short version
4 companies supply this market — a reasonable cushion if one runs into trouble.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
carbidopa, levodopa and entacapone
carbidopa, levodopa and entacapone · CARBIDOPA 25 mg/1; LEVODOPA 100 mg/1; ENTACAPONE 200 mg/1 · Tablet, Film Coated · Oral · Alembic Pharmaceuticals Limited
NDC 46708-0797-31 · 100 TABLET, FILM COATED in 1 BOTTLE · ANDA · View full market →
Medicare Part D
All Part D pricing →Matched to CMS's representative package for this drug (NDC 16571-0691-01) — same generic, strength, and dosage form. CMS prices one NDC per drug concept, not every package.
ⓘ How this was built
Data sources
- CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method
Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
Plans pay at point of saleⓘ
$1.19per unit
middle half $1.02–$1.47 · 5,089 plans · Apr 1, 2026
Est. net of rebatesⓘ
≈ $1.19
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
93%of plans cover it
tier 4 · prior auth 0% · step therapy 0% · qty limit 0%
*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 5 quarters since 2024.
NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
90-day shortage risk (model v2)
0.1%chance of a new FDA shortage posting for carbidopa, levodopa and entacapone (oral solid) in the next 90 days
sole-source market · 1 Class I/II recall(s) in 12 months
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Where it's made
- manufacture
Establishments this product's FDA label declares, located via FDA registration data. How we built this →
Regulatory
- Application
- ANDA218535
- TE code
- AB
- Approval date
- Feb 5, 2026
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of carbidopa, levodopa and entacapone (Tablet, Film Coated)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Alembic Pharmaceuticals Inc. | CARBIDOPA 31.25 mg/1; LEVODOPA 125 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Inc. | CARBIDOPA 50 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 200 mg/1 | Jul 22, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Inc. | CARBIDOPA 12.5 mg/1; LEVODOPA 50 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Inc. | CARBIDOPA 37.5 mg/1; LEVODOPA 150 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Inc. | CARBIDOPA 18.75 mg/1; LEVODOPA 75 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Inc. | CARBIDOPA 25 mg/1; LEVODOPA 100 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Limited | CARBIDOPA 25 mg/1; LEVODOPA 100 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Limited | CARBIDOPA 31.25 mg/1; LEVODOPA 125 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Limited | CARBIDOPA 18.75 mg/1; LEVODOPA 75 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Limited | CARBIDOPA 50 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 200 mg/1 | Jul 22, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Limited | CARBIDOPA 37.5 mg/1; LEVODOPA 150 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Limited | CARBIDOPA 12.5 mg/1; LEVODOPA 50 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Macleods Pharmaceuticals Limited | CARBIDOPA 25 mg/1; LEVODOPA 100 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Macleods Pharmaceuticals Limited | CARBIDOPA 18.75 mg/1; LEVODOPA 75 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Macleods Pharmaceuticals Limited | CARBIDOPA 31.25 mg/1; LEVODOPA 125 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Macleods Pharmaceuticals Limited | CARBIDOPA 12.5 mg/1; LEVODOPA 50 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Macleods Pharmaceuticals Limited | CARBIDOPA 37.5 mg/1; LEVODOPA 150 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Macleods Pharmaceuticals Limited | CARBIDOPA 50 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 200 mg/1 | Jul 22, 2026 | Sep 2, 2026 |
| Rising Pharma Holdings, Inc. | CARBIDOPA 18.75 mg/1; LEVODOPA 75 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Rising Pharma Holdings, Inc. | CARBIDOPA 31.25 mg/1; LEVODOPA 125 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Rising Pharma Holdings, Inc. | CARBIDOPA 50 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 200 mg/1 | Jul 22, 2026 | Sep 2, 2026 |
| Rising Pharma Holdings, Inc. | CARBIDOPA 12.5 mg/1; LEVODOPA 50 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Rising Pharma Holdings, Inc. | CARBIDOPA 25 mg/1; LEVODOPA 100 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Rising Pharma Holdings, Inc. | CARBIDOPA 37.5 mg/1; LEVODOPA 150 mg/1; ENTACAPONE 200 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Alembic Pharmaceuticals Inc. | CARBIDOPA 25 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 100 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Alembic Pharmaceuticals Inc. | CARBIDOPA 12.5 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 50 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Alembic Pharmaceuticals Inc. | CARBIDOPA 37.5 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 150 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Alembic Pharmaceuticals Inc. | CARBIDOPA 18.75 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 75 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Alembic Pharmaceuticals Inc. | CARBIDOPA 31.25 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 125 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Alembic Pharmaceuticals Limited | CARBIDOPA 31.25 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 125 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Alembic Pharmaceuticals Limited | CARBIDOPA 18.75 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 75 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Alembic Pharmaceuticals Limited | CARBIDOPA 37.5 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 150 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Alembic Pharmaceuticals Limited | CARBIDOPA 25 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 100 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Alembic Pharmaceuticals Limited | CARBIDOPA 12.5 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 50 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Macleods Pharmaceuticals Limited | CARBIDOPA 25 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 100 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Macleods Pharmaceuticals Limited | CARBIDOPA 12.5 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 50 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Macleods Pharmaceuticals Limited | CARBIDOPA 18.75 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 75 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Macleods Pharmaceuticals Limited | CARBIDOPA 31.25 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 125 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Macleods Pharmaceuticals Limited | CARBIDOPA 37.5 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 150 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Rising Pharma Holdings, Inc. | CARBIDOPA 12.5 mg/1; LEVODOPA 200 mg/1; ENTACAPONE 50 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "carbidopa, levodopa and entacapone — NDC 46708-0797-31," retrieved September 3, 2026, https://drugdashboards.com/drug/46708079731.
Free to cite with attribution — see how the data is put together.