DrugDashboards

Climara

Estradiol · ESTRADIOL .0375 mg/d · Patch · Transdermal · Bayer HealthCare Pharmaceuticals Inc.

NDC 50419-0456-04 · 4 PATCH in 1 CARTON / 7 d in 1 PATCH · NDA · View full market →

The short version

6 companies supply this market — a reasonable cushion if one runs into trouble. The brand price has held steady around $18.30 per unit over the past year. Generic versions run $10.80 per unit1.7× cheaper. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$18.30per EAinvoice-surveyed acquisition cost · Aug 19, 2026
  • Part D plans paid (avg)$13.21per dosage unitgross, before rebates — matched by drug name · 2024
  • Part D point of sale (median)$10.34per unitnegotiated price across 130 plans — before rebates · Apr 1, 2026
  • Federal ceiling (Big4)$3.85per unitBayer HealthCare Pharmaceuticals, Inc. · Jan 1, 202621% of what pharmacies pay — a deeper discount than 95% of drugs with this benchmark
  • Medicaid generic ceiling (FUL)$14.90per TDPweighted avg manufacturer price $8.0740 · Feb 1, 202081% of what pharmacies pay — a deeper discount than 95% of drugs with this benchmark

Medicare Part D

All Part D pricing →
ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$10.34per unit
middle half $10.29$14.65 · 130 plans · Apr 1, 2026
Est. net of rebates
$6.20–$7.75
brand drug — est. 25-40% rebate off the price at left
Coverage & restrictions
2%of plans cover it
tier 2 · prior auth 12% · step therapy 0% · qty limit 0%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.

NADAC price per unit

$0$20.00$40.00Oct 2013Sep 2026$18.30
38 price points · per EA · dashed = manufacturer avg (WAMP)Source: CMS NADAC

Estimated fill cost

WAC per package, as filed
$76.30
Reported to Texas DSHS · 2026 annual filing · Bayer Healthcare Pharmaceuticals, Inc

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicaid spend (2025)

$286,116
1,797 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

0Low risk

Nothing here is signaling trouble: several manufacturers, no current shortage, no recent serious recalls, stable pricing. In drug supply, boring is the good outcome.

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for estradiol (other) in the next 90 days

sole-source market · 1 Class I/II recall(s) in 12 months

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Regulatory

Application
NDA020375
TE code
AB2
Approval date
Dec 22, 1994
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Estradiol (Patch)

LabelerStrengthFirst seenLast seen
Mylan Pharmaceuticals Inc.ESTRADIOL .075 mg/dJul 15, 2026Sep 3, 2026
Mylan Pharmaceuticals Inc.ESTRADIOL .1 mg/dJul 15, 2026Sep 3, 2026
Mylan Pharmaceuticals Inc.ESTRADIOL .0375 mg/dJul 15, 2026Sep 3, 2026
Mylan Pharmaceuticals Inc.ESTRADIOL .05 mg/dJul 15, 2026Sep 3, 2026
A-S Medication SolutionsESTRADIOL .075 mg/dJul 15, 2026Sep 2, 2026
A-S Medication SolutionsESTRADIOL .0375 mg/dJul 15, 2026Sep 2, 2026
A-S Medication SolutionsESTRADIOL .1 mg/dJul 15, 2026Sep 2, 2026
A-S Medication SolutionsESTRADIOL .025 mg/dJul 15, 2026Sep 2, 2026
A-S Medication SolutionsESTRADIOL .05 mg/dJul 15, 2026Sep 2, 2026
A-S Medication SolutionsESTRADIOL .06 mg/dJul 15, 2026Sep 2, 2026
Bayer HealthCare Pharmaceuticals Inc.ESTRADIOL .075 mg/dJul 15, 2026Sep 2, 2026
Bayer HealthCare Pharmaceuticals Inc.ESTRADIOL .06 mg/dJul 15, 2026Sep 2, 2026
Bayer HealthCare Pharmaceuticals Inc.ESTRADIOL .025 mg/dJul 15, 2026Sep 2, 2026
Bayer HealthCare Pharmaceuticals Inc.ESTRADIOL 14 ug/dJul 15, 2026Sep 2, 2026
Bayer HealthCare Pharmaceuticals Inc.ESTRADIOL .1 mg/dJul 15, 2026Sep 2, 2026
Bayer HealthCare Pharmaceuticals Inc.ESTRADIOL .05 mg/dJul 15, 2026Sep 2, 2026
Bayer HealthCare Pharmaceuticals Inc.ESTRADIOL .0375 mg/dJul 15, 2026Sep 2, 2026
Mylan Pharmaceuticals Inc.ESTRADIOL .06 mg/dJul 15, 2026Sep 2, 2026
Sandoz IncESTRADIOL .06 mg/dJul 15, 2026Sep 2, 2026
Sandoz IncESTRADIOL .075 mg/dJul 15, 2026Sep 2, 2026
Sandoz IncESTRADIOL .025 mg/dJul 15, 2026Sep 2, 2026
Sandoz IncESTRADIOL .0375 mg/dJul 15, 2026Sep 2, 2026
Sandoz IncESTRADIOL .1 mg/dJul 15, 2026Sep 2, 2026
Sandoz IncESTRADIOL .05 mg/dJul 15, 2026Sep 2, 2026
Zydus Lifesciences LimitedESTRADIOL .014 mg/dJul 15, 2026Sep 2, 2026
Zydus Lifesciences LimitedESTRADIOL .025 mg/dJul 15, 2026Sep 2, 2026
Zydus Lifesciences LimitedESTRADIOL .0375 mg/dJul 15, 2026Sep 2, 2026
Zydus Lifesciences LimitedESTRADIOL .05 mg/dJul 15, 2026Sep 2, 2026
Zydus Lifesciences LimitedESTRADIOL .06 mg/dJul 15, 2026Sep 2, 2026
Zydus Lifesciences LimitedESTRADIOL .075 mg/dJul 15, 2026Sep 2, 2026
Zydus Lifesciences LimitedESTRADIOL .1 mg/dJul 15, 2026Sep 2, 2026
Zydus Pharmaceuticals USA Inc.ESTRADIOL .075 mg/dJul 15, 2026Sep 2, 2026
Zydus Pharmaceuticals USA Inc.ESTRADIOL .05 mg/dJul 15, 2026Sep 2, 2026
Zydus Pharmaceuticals USA Inc.ESTRADIOL .0375 mg/dJul 15, 2026Sep 2, 2026
Zydus Pharmaceuticals USA Inc.ESTRADIOL .025 mg/dJul 15, 2026Sep 2, 2026
Zydus Pharmaceuticals USA Inc.ESTRADIOL .1 mg/dJul 15, 2026Sep 2, 2026
Zydus Pharmaceuticals USA Inc.ESTRADIOL .014 mg/dJul 15, 2026Sep 2, 2026
Zydus Pharmaceuticals USA Inc.ESTRADIOL .06 mg/dJul 15, 2026Sep 2, 2026
Mylan Pharmaceuticals Inc.ESTRADIOL .025 mg/dJul 15, 2026Aug 31, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Climara — NDC 50419-0456-04," retrieved September 3, 2026, https://drugdashboards.com/drug/50419045604.

Free to cite with attribution — see how the data is put together.