DrugDashboards

Promethazine Hydrochloride and Dextromethorphan Hydrobromide

Promethazine Hydrochloride and Dextromethorphan Hydrobromide · PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL · Solution · Oral · Amneal Pharmaceuticals LLC

NDC 65162-0680-86 · 118 mL in 1 BOTTLE · ANDA · View full market →

The short version

10 companies supply this market — deep enough that no single failure threatens the supply. The price has jumped 42% in a year, to $0.0510 per mL — sharp rises like this often mean supply is already tightening. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$0.0510per MLinvoice-surveyed acquisition cost · Jul 23, 2025
  • Medicaid generic ceiling (FUL)$0.0430per MLweighted avg manufacturer price $0.0245 · Aug 1, 202684% of what pharmacies pay — a deeper discount than 95% of drugs with this benchmark

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

$0$0.025$0.05$0.075May 2020Jul 2025$0.051
42 price points · per ML · last surveyed Invalid Date · dashed = manufacturer avg (WAMP)Source: CMS NADAC

Estimated fill cost

WAC per package, as filed
$8.75
Reported to Texas DSHS · 2026 annual filing · Amneal Pharmaceuticals LLC

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicaid spend (2025)

$12,996
691 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

0● Low risk

Nothing here is signaling trouble: several manufacturers, no current shortage, no recent serious recalls, stable pricing. In drug supply, boring is the good outcome.

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for promethazine hydrochloride and dextromethorphan hydrobromide (other) in the next 90 days

sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Regulatory

Application
ANDA090575
TE code
AA
Approval date
Feb 8, 2011
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Promethazine Hydrochloride and Dextromethorphan Hydrobromide (Solution)

LabelerStrengthFirst seenLast seen
A-S Medication SolutionsPROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mLAug 26, 2026Sep 2, 2026
Advagen Pharma LtdPROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mLAug 26, 2026Sep 2, 2026
Amneal Pharmaceuticals LLCPROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mLAug 26, 2026Sep 2, 2026
ANI Pharmaceuticals, Inc.PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mLAug 26, 2026Sep 2, 2026
Asclemed USA, Inc.PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mLAug 26, 2026Sep 2, 2026
Bryant Ranch PrepackPROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mLAug 26, 2026Sep 2, 2026
Camber Pharmaceuticals, Inc.PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mLAug 26, 2026Sep 2, 2026
Cosette Pharmaceuticals, Inc.PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mLAug 26, 2026Sep 2, 2026
Cranbury Pharmaceuticals, LLCPROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mLAug 26, 2026Sep 2, 2026
PAI Holdings, LLC dba PAI PharmaDEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mLJul 15, 2026Sep 2, 2026
A-S Medication SolutionsPROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mLJul 22, 2026Aug 19, 2026
Advagen Pharma LtdPROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mLJul 22, 2026Aug 19, 2026
Amneal Pharmaceuticals LLCPROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mLJul 22, 2026Aug 19, 2026
ANI Pharmaceuticals, Inc.PROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mLJul 22, 2026Aug 19, 2026
Asclemed USA, Inc.PROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mLJul 22, 2026Aug 19, 2026
Bryant Ranch PrepackPROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mLJul 22, 2026Aug 19, 2026
Camber Pharmaceuticals, Inc.PROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mLJul 22, 2026Aug 19, 2026
Cosette Pharmaceuticals, Inc.PROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mLJul 22, 2026Aug 19, 2026
Cranbury Pharmaceuticals, LLCPROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mLJul 22, 2026Aug 19, 2026
A-S Medication SolutionsDEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mLJul 15, 2026Jul 15, 2026
Advagen Pharma LtdDEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mLJul 15, 2026Jul 15, 2026
Amneal Pharmaceuticals LLCDEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mLJul 15, 2026Jul 15, 2026
ANI Pharmaceuticals, Inc.DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mLJul 15, 2026Jul 15, 2026
Asclemed USA, Inc.DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mLJul 15, 2026Jul 15, 2026
Bryant Ranch PrepackDEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mLJul 15, 2026Jul 15, 2026
Camber Pharmaceuticals, Inc.DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mLJul 15, 2026Jul 15, 2026
Cosette Pharmaceuticals, Inc.DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mLJul 15, 2026Jul 15, 2026
Cranbury Pharmaceuticals, LLCDEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mLJul 15, 2026Jul 15, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Promethazine Hydrochloride and Dextromethorphan Hydrobromide — NDC 65162-0680-86," retrieved September 3, 2026, https://drugdashboards.com/drug/65162068086.

Free to cite with attribution — see how the data is put together.