The short version
10 companies supply this market — deep enough that no single failure threatens the supply.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Promethazine Hydrochloride and Dextromethorphan Hydrobromide
Promethazine Hydrochloride and Dextromethorphan Hydrobromide · PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL · Solution · Oral · Advagen Pharma Ltd
NDC 72888-0038-01 · 473 mL in 1 BOTTLE · ANDA · View full market →
Medicare Part D
No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.
How Part D pricing works →NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
90-day shortage risk (model v2)
0.1%chance of a new FDA shortage posting for promethazine hydrochloride and dextromethorphan hydrobromide (other) in the next 90 days
sole-source market
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Regulatory
- Application
- ANDA220869
- TE code
- AA
- Approval date
- Jun 23, 2026
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of Promethazine Hydrochloride and Dextromethorphan Hydrobromide (Solution)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| A-S Medication Solutions | PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL | Aug 26, 2026 | Sep 2, 2026 |
| Advagen Pharma Ltd | PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL | Aug 26, 2026 | Sep 2, 2026 |
| Amneal Pharmaceuticals LLC | PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL | Aug 26, 2026 | Sep 2, 2026 |
| ANI Pharmaceuticals, Inc. | PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL | Aug 26, 2026 | Sep 2, 2026 |
| Asclemed USA, Inc. | PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL | Aug 26, 2026 | Sep 2, 2026 |
| Bryant Ranch Prepack | PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL | Aug 26, 2026 | Sep 2, 2026 |
| Camber Pharmaceuticals, Inc. | PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL | Aug 26, 2026 | Sep 2, 2026 |
| Cosette Pharmaceuticals, Inc. | PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL | Aug 26, 2026 | Sep 2, 2026 |
| Cranbury Pharmaceuticals, LLC | PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL | Aug 26, 2026 | Sep 2, 2026 |
| PAI Holdings, LLC dba PAI Pharma | DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL | Jul 15, 2026 | Sep 2, 2026 |
| A-S Medication Solutions | PROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mL | Jul 22, 2026 | Aug 19, 2026 |
| Advagen Pharma Ltd | PROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mL | Jul 22, 2026 | Aug 19, 2026 |
| Amneal Pharmaceuticals LLC | PROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mL | Jul 22, 2026 | Aug 19, 2026 |
| ANI Pharmaceuticals, Inc. | PROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mL | Jul 22, 2026 | Aug 19, 2026 |
| Asclemed USA, Inc. | PROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mL | Jul 22, 2026 | Aug 19, 2026 |
| Bryant Ranch Prepack | PROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mL | Jul 22, 2026 | Aug 19, 2026 |
| Camber Pharmaceuticals, Inc. | PROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mL | Jul 22, 2026 | Aug 19, 2026 |
| Cosette Pharmaceuticals, Inc. | PROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mL | Jul 22, 2026 | Aug 19, 2026 |
| Cranbury Pharmaceuticals, LLC | PROMETHAZINE HYDROCHLORIDE 15 mg/5mL; DEXTROMETHORPHAN HYDROBROMIDE 6.25 mg/5mL | Jul 22, 2026 | Aug 19, 2026 |
| A-S Medication Solutions | DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL | Jul 15, 2026 | Jul 15, 2026 |
| Advagen Pharma Ltd | DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL | Jul 15, 2026 | Jul 15, 2026 |
| Amneal Pharmaceuticals LLC | DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL | Jul 15, 2026 | Jul 15, 2026 |
| ANI Pharmaceuticals, Inc. | DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL | Jul 15, 2026 | Jul 15, 2026 |
| Asclemed USA, Inc. | DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL | Jul 15, 2026 | Jul 15, 2026 |
| Bryant Ranch Prepack | DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL | Jul 15, 2026 | Jul 15, 2026 |
| Camber Pharmaceuticals, Inc. | DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL | Jul 15, 2026 | Jul 15, 2026 |
| Cosette Pharmaceuticals, Inc. | DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL | Jul 15, 2026 | Jul 15, 2026 |
| Cranbury Pharmaceuticals, LLC | DEXTROMETHORPHAN HYDROBROMIDE 15 mg/5mL; PROMETHAZINE HYDROCHLORIDE 6.25 mg/5mL | Jul 15, 2026 | Jul 15, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Promethazine Hydrochloride and Dextromethorphan Hydrobromide — NDC 72888-0038-01," retrieved September 3, 2026, https://drugdashboards.com/drug/72888003801.
Free to cite with attribution — see how the data is put together.