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Piperacillin and Tazobactam

Piperacillin and Tazobactam · PIPERACILLIN SODIUM 36 g/180mL; TAZOBACTAM SODIUM 4.5 g/180mL · Injection, Powder, For Solution · Intravenous · Fresenius Kabi USA, LLC

NDC 65219-0256-28 · 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON / 180 mL in 1 VIAL, PHARMACY BULK PACKAGE · ANDA · View full market →

The short version

9 companies supply this market — a reasonable cushion if one runs into trouble. Historically, drugs in this position went on to a new shortage within 90 days about 0.4% of the time — roughly 3× the typical drug (0.1%).

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.

Estimated fill cost

WAC per package, as filed
$46.50
Reported to Texas DSHS · 2026 annual filing · Fresenius Kabi USA

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicare Part B (ASP)

Payment limit per 1.125 GM
$1.218
HCPCS J2543 · Jul 1, 2026 quarter · typically ASP + 6%

Medicaid spend (2025)

$16,235
296 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

Not scored — fragility is computed for NADAC-priced NDCs.

90-day shortage risk (model v2)

0.4%chance of a new FDA shortage posting for piperacillin and tazobactam (injectable) in the next 90 days

sterile injectable · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is 3× that.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

  • Mitim S.r.l.Italy
    analysis · label · manufacture · pack · sterilize

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier
  • Costs ≥ $950/fill
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program

Regulatory

Application
ANDA203720
TE code
AP
Approval date
May 11, 2018
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Piperacillin and Tazobactam (Injection, Powder, For Solution)

LabelerStrengthFirst seenLast seen
Fresenius Kabi USA, LLCPIPERACILLIN SODIUM 36 g/180mL; TAZOBACTAM SODIUM 4.5 g/180mLJul 15, 2026Sep 3, 2026
Apotex Corp.PIPERACILLIN SODIUM 3 g/15mL; TAZOBACTAM SODIUM .375 g/15mLJul 15, 2026Sep 2, 2026
Apotex Corp.PIPERACILLIN SODIUM 4 g/20mL; TAZOBACTAM SODIUM .5 g/20mLJul 15, 2026Sep 2, 2026
Apotex Corp.PIPERACILLIN SODIUM 2 g/10mL; TAZOBACTAM SODIUM .25 g/10mLJul 15, 2026Sep 2, 2026
Armas Pharmaceuticals Inc.PIPERACILLIN SODIUM 3 g/15mL; TAZOBACTAM SODIUM .375 g/15mLJul 15, 2026Sep 2, 2026
Armas Pharmaceuticals Inc.PIPERACILLIN SODIUM 4 g/20mL; TAZOBACTAM SODIUM .5 g/20mLJul 15, 2026Sep 2, 2026
Avenacy, LLCPIPERACILLIN SODIUM 2 g/10mL; TAZOBACTAM SODIUM .25 g/10mLJul 15, 2026Sep 2, 2026
Avenacy, LLCPIPERACILLIN SODIUM 36 g/180mL; TAZOBACTAM SODIUM 4.5 g/180mLJul 15, 2026Sep 2, 2026
Avenacy, LLCPIPERACILLIN SODIUM 3 g/15mL; TAZOBACTAM SODIUM .375 g/15mLJul 15, 2026Sep 2, 2026
Avenacy, LLCPIPERACILLIN SODIUM 4 g/20mL; TAZOBACTAM SODIUM .5 g/20mLJul 15, 2026Sep 2, 2026
BluePoint LaboratoriesPIPERACILLIN SODIUM 2 g/10mL; TAZOBACTAM SODIUM .25 g/10mLJul 15, 2026Sep 2, 2026
BluePoint LaboratoriesPIPERACILLIN SODIUM 3 g/15mL; TAZOBACTAM SODIUM .375 g/15mLJul 15, 2026Sep 2, 2026
BluePoint LaboratoriesPIPERACILLIN SODIUM 4 g/20mL; TAZOBACTAM SODIUM .5 g/20mLJul 15, 2026Sep 2, 2026
Civica, Inc.PIPERACILLIN SODIUM 4 g/20mL; TAZOBACTAM SODIUM .5 g/20mLJul 15, 2026Sep 2, 2026
Civica, Inc.PIPERACILLIN SODIUM 3 g/15mL; TAZOBACTAM SODIUM .375 g/15mLJul 15, 2026Sep 2, 2026
Onesource Specialty Pharma LimitedPIPERACILLIN SODIUM 2 g/10mL; TAZOBACTAM SODIUM .25 g/10mLJul 15, 2026Sep 2, 2026
Onesource Specialty Pharma LimitedPIPERACILLIN SODIUM 3 g/15mL; TAZOBACTAM SODIUM .375 g/15mLJul 15, 2026Sep 2, 2026
Onesource Specialty Pharma LimitedPIPERACILLIN SODIUM 4 g/20mL; TAZOBACTAM SODIUM .5 g/20mLJul 15, 2026Sep 2, 2026
Shandong Anxin Pharmaceutical Co., Ltd.PIPERACILLIN SODIUM 3 g/15mL; TAZOBACTAM SODIUM .375 g/15mLJul 15, 2026Sep 2, 2026
Shandong Anxin Pharmaceutical Co., Ltd.PIPERACILLIN SODIUM 2 g/10mL; TAZOBACTAM SODIUM .25 g/10mLJul 15, 2026Sep 2, 2026
Shandong Anxin Pharmaceutical Co., Ltd.PIPERACILLIN SODIUM 4 g/20mL; TAZOBACTAM SODIUM .5 g/20mLJul 15, 2026Sep 2, 2026
WG Critical Care, LLCPIPERACILLIN SODIUM 36 g/1; TAZOBACTAM SODIUM 4.5 g/1Jul 15, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Piperacillin and Tazobactam — NDC 65219-0256-28," retrieved September 3, 2026, https://drugdashboards.com/drug/65219025628.

Free to cite with attribution — see how the data is put together.