DrugDashboards

Fluticasone Propionate and Salmeterol DISKUS

fluticasone propionate and salmeterol · FLUTICASONE PROPIONATE 250 ug/1; SALMETEROL XINAFOATE 50 ug/1 · Powder · Respiratory (Inhalation) · Prasco Laboratories

NDC 66993-0585-97 · 1 INHALER in 1 CARTON / 60 POWDER in 1 INHALER · NDA AUTHORIZED GENERIC · View full market →

The short version

12 companies supply this market — deep enough that no single failure threatens the supply. The generic price has held steady around $1.28 per unit over the past year. The brand (Advair Diskus) runs $3.12 per unit 2.4× more. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$1.28per EAinvoice-surveyed acquisition cost · Aug 19, 2026
  • Part D point of sale (median)$1.66per unitnegotiated price across 5,107 plans — before rebates · Apr 1, 2026

Medicare Part D

All Part D pricing →
ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$1.66per unit
middle half $1.36$2.10 · 5,107 plans · Apr 1, 2026
Est. net of rebates
≈ $1.66
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
93%of plans cover it
tier 3 · prior auth 0% · step therapy 0% · qty limit 99%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.

NADAC price per unit

$0$2.00$4.00Apr 2019Sep 2026$1.28
90 price points · per EASource: CMS NADAC

Medicaid spend (2025)

$6.5M
68,863 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

0Low risk

Nothing here is signaling trouble: several manufacturers, no current shortage, no recent serious recalls, stable pricing. In drug supply, boring is the good outcome.

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for fluticasone propionate and salmeterol (other) in the next 90 days

sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Regulatory

Application
NDA021077
TE code
AB
Approval date
Aug 24, 2000
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of fluticasone propionate and salmeterol (Powder)

LabelerStrengthFirst seenLast seen
A-S Medication SolutionsFLUTICASONE PROPIONATE 100 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Sep 2, 2026
A-S Medication SolutionsFLUTICASONE PROPIONATE 250 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Sep 2, 2026
Bryant Ranch PrepackFLUTICASONE PROPIONATE 250 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Sep 2, 2026
GlaxoSmithKline LLCSALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 100 ug/1Aug 26, 2026Sep 2, 2026
GlaxoSmithKline LLCSALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 500 ug/1Aug 26, 2026Sep 2, 2026
GlaxoSmithKline LLCSALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 250 ug/1Aug 26, 2026Sep 2, 2026
Hikma Pharmaceuticals USA Inc.SALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 100 ug/1Aug 26, 2026Sep 2, 2026
Hikma Pharmaceuticals USA Inc.SALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 500 ug/1Aug 26, 2026Sep 2, 2026
Hikma Pharmaceuticals USA Inc.SALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 250 ug/1Aug 26, 2026Sep 2, 2026
Lannett Company, Inc.SALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 250 ug/1Aug 26, 2026Sep 2, 2026
Lannett Company, Inc.SALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 100 ug/1Aug 26, 2026Sep 2, 2026
Mylan Pharmaceuticals Inc.FLUTICASONE PROPIONATE 250 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Sep 2, 2026
Mylan Pharmaceuticals Inc.FLUTICASONE PROPIONATE 100 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Sep 2, 2026
Mylan Pharmaceuticals Inc.FLUTICASONE PROPIONATE 500 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Sep 2, 2026
Prasco LaboratoriesFLUTICASONE PROPIONATE 100 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Sep 2, 2026
Prasco LaboratoriesFLUTICASONE PROPIONATE 250 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Sep 2, 2026
Prasco LaboratoriesFLUTICASONE PROPIONATE 500 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Sep 2, 2026
Preferred Pharmaceuticals Inc.SALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 250 ug/1Aug 26, 2026Sep 2, 2026
Preferred Pharmaceuticals Inc.SALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 100 ug/1Aug 26, 2026Sep 2, 2026
Proficient Rx LPFLUTICASONE PROPIONATE 250 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Sep 2, 2026
Remedyrepack Inc.SALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 250 ug/1Aug 26, 2026Sep 2, 2026
Remedyrepack Inc.FLUTICASONE PROPIONATE 500 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Sep 2, 2026
Remedyrepack Inc.SALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 100 ug/1Aug 26, 2026Sep 2, 2026
Teva Pharmaceuticals USA, Inc.FLUTICASONE PROPIONATE 100 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Sep 2, 2026
Teva Pharmaceuticals USA, Inc.FLUTICASONE PROPIONATE 500 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Sep 2, 2026
Teva Pharmaceuticals USA, Inc.FLUTICASONE PROPIONATE 250 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Sep 2, 2026
A-S Medication SolutionsSALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 500 ug/1Aug 26, 2026Aug 31, 2026
A-S Medication SolutionsSALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 100 ug/1Aug 26, 2026Aug 31, 2026
A-S Medication SolutionsSALMETEROL XINAFOATE 50 ug/1; FLUTICASONE PROPIONATE 250 ug/1Aug 26, 2026Aug 31, 2026
A-S Medication SolutionsFLUTICASONE PROPIONATE 500 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Aug 30, 2026
Remedyrepack Inc.FLUTICASONE PROPIONATE 100 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Aug 30, 2026
Remedyrepack Inc.FLUTICASONE PROPIONATE 250 ug/1; SALMETEROL XINAFOATE 50 ug/1Jul 15, 2026Aug 30, 2026
Cipla USA Inc.FLUTICASONE PROPIONATE 100 ug/1; SALMETEROL XINAFOATE 50 ug/1Aug 1, 2026Aug 29, 2026
Cipla USA Inc.FLUTICASONE PROPIONATE 250 ug/1; SALMETEROL XINAFOATE 50 ug/1Aug 1, 2026Aug 29, 2026
Cipla USA Inc.FLUTICASONE PROPIONATE 500 ug/1; SALMETEROL XINAFOATE 50 ug/1Aug 1, 2026Aug 29, 2026
A-S Medication SolutionsSALMETEROL XINAFOATE 100 ug/1; FLUTICASONE PROPIONATE 50 ug/1Jul 22, 2026Aug 22, 2026
A-S Medication SolutionsSALMETEROL XINAFOATE 250 ug/1; FLUTICASONE PROPIONATE 50 ug/1Jul 22, 2026Aug 22, 2026
A-S Medication SolutionsSALMETEROL XINAFOATE 500 ug/1; FLUTICASONE PROPIONATE 50 ug/1Jul 22, 2026Aug 20, 2026
GlaxoSmithKline LLCSALMETEROL XINAFOATE 500 ug/1; FLUTICASONE PROPIONATE 50 ug/1Jul 22, 2026Aug 19, 2026
GlaxoSmithKline LLCSALMETEROL XINAFOATE 250 ug/1; FLUTICASONE PROPIONATE 50 ug/1Jul 22, 2026Aug 19, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Fluticasone Propionate and Salmeterol DISKUS — NDC 66993-0585-97," retrieved September 3, 2026, https://drugdashboards.com/drug/66993058597.

Free to cite with attribution — see how the data is put together.