The short version
12 companies supply this market — deep enough that no single failure threatens the supply.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Butalbital, Acetaminophen And Caffeine
butalbital, acetaminophen and caffeine · ACETAMINOPHEN 300 mg/1; CAFFEINE 40 mg/1; BUTALBITAL 50 mg/1 · Capsule · Oral · Bryant Ranch Prepack
NDC 72162-1232-01 · 100 CAPSULE in 1 BOTTLE · ANDA · View full market →
Medicare Part D
All Part D pricing →Matched to CMS's representative package for this drug (NDC 11534-0187-01) — same generic, strength, and dosage form. CMS prices one NDC per drug concept, not every package.
ⓘ How this was built
Data sources
- CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method
Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
Plans pay at point of saleⓘ
$0.6441per unit
middle half $0.5372–$0.7653 · 470 plans · Apr 1, 2026
Est. net of rebatesⓘ
≈ $0.6441
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
9%of plans cover it
tier 3 · prior auth 68% · step therapy 0% · qty limit 97%
*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.
NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
90-day shortage risk (model v2)
0.1%chance of a new FDA shortage posting for butalbital, acetaminophen and caffeine (oral solid) in the next 90 days
OAI inspection at a producing facility (24 months) · sole-source market
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Where it's made
- Bryant Ranch PrepackUnited Statesrelabel · repack
Establishments this product's FDA label declares, located via FDA registration data. How we built this →
Is this a "specialty" drug?
There's no legal definition — it meets 1 of 6 public criteria. Why that matters →
- Part D specialty tier
- Costs ≥ $950/fill
- Biologic (BLA)
- Injectable / infused
- Orphan-drug exclusivity
- REMS program · Opioid Analgesic REMS Shared System REMS
Regulatory
- Application
- ANDA207118
- TE code
- AA
- Approval date
- Oct 28, 2016
- Patents / exclusivity
- None on file
Shortage history
No FDA shortage reports for this drug or its presentations.
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of butalbital, acetaminophen and caffeine (Capsule)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Bryant Ranch Prepack | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Bryant Ranch Prepack | ACETAMINOPHEN 300 mg/1; CAFFEINE 40 mg/1; BUTALBITAL 50 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Advanced Rx of Tennessee, LLC | BUTALBITAL 50 mg/1; ACETAMINOPHEN 300 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Amici Pharma, Inc. | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Aurolife Pharma, LLC | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Dr. Reddy's Labratories Inc. | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Granules Pharmaceuticals Inc. | BUTALBITAL 50 mg/1; ACETAMINOPHEN 300 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Lannett Company, Inc. | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Mayne Pharma | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Quagen Pharmaceuticals Llc | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Quagen Pharmaceuticals Llc | BUTALBITAL 50 mg/1; ACETAMINOPHEN 300 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Seton Pharmaceuticals LLC | BUTALBITAL 50 mg/1; ACETAMINOPHEN 325 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Seton Pharmaceuticals LLC | BUTALBITAL 50 mg/1; ACETAMINOPHEN 300 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Solco Healthcare Us, Llc | BUTALBITAL 50 mg/1; ACETAMINOPHEN 300 mg/1; CAFFEINE 40 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Sunrise Pharmaceutical, Inc | ACETAMINOPHEN 300 mg/1; CAFFEINE 40 mg/1; BUTALBITAL 50 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Bryant Ranch Prepack | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 22, 2026 |
| Bryant Ranch Prepack | ACETAMINOPHEN 300 mg/1; CAFFEINE 50 mg/1; BUTALBITAL 40 mg/1 | Jul 22, 2026 | Aug 21, 2026 |
| Advanced Rx of Tennessee, LLC | BUTALBITAL 300 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Amici Pharma, Inc. | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Aurolife Pharma, LLC | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Dr. Reddy's Labratories Inc. | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Granules Pharmaceuticals Inc. | BUTALBITAL 300 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Lannett Company, Inc. | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Mayne Pharma | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Quagen Pharmaceuticals Llc | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Quagen Pharmaceuticals Llc | BUTALBITAL 300 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Seton Pharmaceuticals LLC | BUTALBITAL 300 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Seton Pharmaceuticals LLC | BUTALBITAL 325 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Solco Healthcare Us, Llc | BUTALBITAL 300 mg/1; ACETAMINOPHEN 50 mg/1; CAFFEINE 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Sunrise Pharmaceutical, Inc | ACETAMINOPHEN 300 mg/1; CAFFEINE 50 mg/1; BUTALBITAL 40 mg/1 | Jul 22, 2026 | Aug 19, 2026 |
| Bryant Ranch Prepack | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 19, 2026 |
| Bryant Ranch Prepack | ACETAMINOPHEN 300 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 19, 2026 |
| Advanced Rx of Tennessee, LLC | ACETAMINOPHEN 300 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Amici Pharma, Inc. | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Aurolife Pharma, LLC | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Dr. Reddy's Labratories Inc. | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Granules Pharmaceuticals Inc. | ACETAMINOPHEN 300 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Lannett Company, Inc. | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Mayne Pharma | ACETAMINOPHEN 325 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
| Quagen Pharmaceuticals Llc | ACETAMINOPHEN 300 mg/1; BUTALBITAL 50 mg/1; CAFFEINE 40 mg/1 | Jul 15, 2026 | Jul 15, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Butalbital, Acetaminophen And Caffeine — NDC 72162-1232-01," retrieved September 3, 2026, https://drugdashboards.com/drug/72162123201.
Free to cite with attribution — see how the data is put together.