DrugDashboards

Infumorph 500

morphine sulfate · MORPHINE SULFATE 25 mg/mL · Injection, Solution · Epidural; Intrathecal · Hikma Pharmaceuticals USA Inc.

NDC 00641-6040-01 · 20 mL in 1 AMPULE · NDA · View full market →

The short version

5 companies supply this market — a reasonable cushion if one runs into trouble. It is in shortage right now — FDA lists the reason as “discontinuation of the manufacture of the drug”.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Medicare Part B pays (ASP+6%)$18.91per billing unit (10 MG)HCPCS J2274 · Jul 1, 2026
  • Part D plans paid (avg)$0.5055per dosage unitgross, before rebates — matched by drug name · 2024

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.

Estimated fill cost

WAC per package, as filed
$353.65
Reported to Texas DSHS · 2026 annual filing · Hikma Pharmaceuticals USA Inc.

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicare Part B (ASP)

Payment limit per 10 MG
$18.914
HCPCS J2274 · Jul 1, 2026 quarter · typically ASP + 6%

Medicaid spend (2025)

$403
16 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

Not scored — fragility is computed for NADAC-priced NDCs.

90-day shortage risk (model v2)

0.5%chance of a new FDA shortage posting for morphine sulfate (injectable) in the next 90 days

sterile injectable · OAI inspection at a producing facility (24 months) · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is 4× that.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Is this a "specialty" drug?

There's no legal definition — it meets 2 of 6 public criteria. Why that matters →

  • Part D specialty tier
  • Costs ≥ $950/fill · avg $28.78 per prescription
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program · Opioid Analgesic REMS Shared System REMS

Regulatory

Application
NDA018565
TE code
AP
Approval date
Sep 18, 1984
Patents / exclusivity
None on file

Shortage history

  • In shortage now — Infumorph 200 (Preservative-Free Morphine Sulfate Sterile Solution), Injection, 10 mg/1 mL (NDC 0641-6039-01)Nov 3, 2017
    month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
  • In shortage now — Infumorph 500 (Preservative-Free Morphine Sulfate Sterile Solution), Injection, 25 mg/1 mL (NDC 0641-6040-01)Nov 3, 2017
    month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
  • In shortage now — Morphine Sulfate, Injection, 10 mg/1 mL (NDC 63323-451-01)Oct 31, 2017
    month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
  • In shortage now — Morphine Sulfate, Injection, 10 mg/1 mL Syringes (NDC 0409-1893-01)Oct 31, 2017
    Discontinuation of the manufacture of the drug
    month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
  • In shortage now — Morphine Sulfate, Injection, 10 mg/10 mL (1 mg/mL) (NDC 0409-3815-12)Oct 31, 2017
    month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
  • In shortage now — Morphine Sulfate, Injection, 2 mg/1 mL (NDC 0409-1890-23)Oct 31, 2017
    Other
    month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
  • In shortage now — Morphine Sulfate, Injection, 2 mg/1 mL (NDC 63323-452-01)Oct 31, 2017
    Other
    month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
  • In shortage now — Morphine Sulfate, Injection, 2 mg/1 mL (NDC 76045-004-11)Oct 31, 2017
    Other
    month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
  • In shortage now — Morphine Sulfate, Injection, 2 mg/1 mL Syringes (NDC 0409-1890-01)Oct 31, 2017
    month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
  • In shortage now — Morphine Sulfate, Injection, 4 mg/1 mL (NDC 63323-454-01)Oct 31, 2017
    Other
    month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
  • In shortage now — Morphine Sulfate, Injection, 4 mg/1 mL (NDC 76045-005-11)Oct 31, 2017
    Other
    month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
  • In shortage now — Morphine Sulfate, Injection, 4 mg/1 mL Syringes (NDC 0409-1891-01)Oct 31, 2017
    month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
  • In shortage now — Morphine Sulfate, Injection, 5 mg/10 mL (0.5 mg/mL) (NDC 0409-3814-12)Oct 31, 2017
    month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
  • In shortage now — Morphine Sulfate, Injection, 50 mg/1 mL (NDC 0409-1896-20)Oct 31, 2017
    Other
    month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months

Recalls (this NDC)

  • Class II · OngoingMar 12, 2024
    Hikma Pharmaceuticals USA Inc. — The filter included in the carton has an expiration date that has expired prior to the expiration date of the actual product lot.

Manufacturers of morphine sulfate (Injection, Solution)

LabelerStrengthFirst seenLast seen
Hospira, Inc.MORPHINE SULFATE 50 mg/mLJul 15, 2026Sep 3, 2026
Bond Pharmacy INCMORPHINE SULFATE 62.5 mg/mLJul 15, 2026Sep 2, 2026
Fresenius Kabi USA, LLCMORPHINE SULFATE 4 mg/mLJul 15, 2026Sep 2, 2026
Fresenius Kabi USA, LLCMORPHINE SULFATE 10 mg/mLJul 15, 2026Sep 2, 2026
Fresenius Kabi USA, LLCMORPHINE SULFATE 2 mg/mLJul 15, 2026Sep 2, 2026
Fresenius Kabi, USA LLCMORPHINE SULFATE 4 mg/mLJul 15, 2026Sep 2, 2026
Fresenius Kabi, USA LLCMORPHINE SULFATE 2 mg/mLJul 15, 2026Sep 2, 2026
Hikma Pharmaceuticals USA Inc.MORPHINE SULFATE 25 mg/mLJul 15, 2026Sep 2, 2026
Hikma Pharmaceuticals USA Inc.MORPHINE SULFATE 10 mg/mLJul 15, 2026Sep 2, 2026
Hospira, Inc.MORPHINE SULFATE 2 mg/mLJul 15, 2026Sep 2, 2026
Hospira, Inc.MORPHINE SULFATE 1 mg/mLJul 15, 2026Sep 2, 2026
Hospira, Inc.MORPHINE SULFATE .5 mg/mLJul 15, 2026Sep 2, 2026
Hospira, Inc.MORPHINE SULFATE 4 mg/mLJul 15, 2026Sep 2, 2026
Hospira, Inc.MORPHINE SULFATE 10 mg/mLJul 15, 2026Aug 29, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Infumorph 500 — NDC 00641-6040-01," retrieved September 3, 2026, https://drugdashboards.com/drug/00641604001.

Free to cite with attribution — see how the data is put together.