Morphine Sulfate

Morphine Sulfate · MORPHINE SULFATE 2 mg/mL · Injection, Solution · Intramuscular; Intravenous · Fresenius Kabi, USA LLC

NDC 76045-0004-11 · 10 SYRINGE, GLASS in 1 CARTON / 1 mL in 1 SYRINGE, GLASS · NDA · View full market →

The short version

5 companies supply this market — a reasonable cushion if one runs into trouble. It is in shortage right now — FDA lists the reason as “discontinuation of the manufacture of the drug”.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built

Data sources

CMS NADAC (pharmacy acquisition, weekly)
CMS Part B ASP quarterly payment limits
CMS Maximum Fair Prices (IRA negotiated, NDC-level)
Medicare Part D Spending by Drug (data.cms.gov, name-matched)
VA FSS / Big4 federal contract prices (va.gov, twice monthly)
ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
California SB-17 WAC filings (list price, per package)

Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Medicare Part B pays (ASP+6%)$8.46per billing unit (10 MG)HCPCS J2272 · Jul 1, 2026
Part D plans paid (avg)$0.5055per dosage unitgross, before rebates — matched by drug name · 2024
Federal ceiling (Big4)$16.83per package of 10X1MLFresenius Kabi, LLC · Jan 1, 2026
List price (WAC, as filed)$35.80per packageFresenius Kabi USA LLC · Jan 12, 2026

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.

Estimated fill cost

WAC per package, as filed

$28.70

Reported to Texas DSHS · 2026 annual filing · Fresenius Kabi USA

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Medicare Part B (ASP)

Payment limit per 10 MG

$8.455

HCPCS J2272 · Jul 1, 2026 quarter · typically ASP + 6%

Medicaid spend (2025)

$249,871

18,951 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

Not scored — fragility is computed for NADAC-priced NDCs.

90-day shortage risk (model v2)

0.5%chance of a new FDA shortage posting for morphine sulfate (injectable) in the next 90 days

sterile injectable · OAI inspection at a producing facility (24 months) · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is 4× that.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

Fresenius Kabi USA, LLCUnited States
analysis · manufacture

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Is this a "specialty" drug?

There's no legal definition — it meets 2 of 6 public criteria. Why that matters →

Part D specialty tier
Costs ≥ $950/fill · avg $28.78 per prescription
Biologic (BLA)
Injectable / infused
Orphan-drug exclusivity
REMS program · Opioid Analgesic REMS Shared System REMS

Regulatory

Application: NDA204223
TE code: —
Approval date: Oct 30, 2013
Patents / exclusivity: 15 patents, 0 exclusivities

Type	Number / code	Expires
patent	9192608	Mar 12, 2034
patent	9192608	Mar 12, 2034
patent	9192608	Mar 12, 2034
patent	9192608	Mar 12, 2034
patent	9192608	Mar 12, 2034
patent	9248229	Mar 12, 2034
patent	9072781	Mar 12, 2034
patent	9248229	Mar 12, 2034
patent	9072781	Mar 12, 2034
patent	9248229	Mar 12, 2034
patent	9072781	Mar 12, 2034
patent	9072781	Mar 12, 2034

Shortage history

In shortage now — Infumorph 200 (Preservative-Free Morphine Sulfate Sterile Solution), Injection, 10 mg/1 mL (NDC 0641-6039-01)Nov 3, 2017
month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
In shortage now — Infumorph 500 (Preservative-Free Morphine Sulfate Sterile Solution), Injection, 25 mg/1 mL (NDC 0641-6040-01)Nov 3, 2017
month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
In shortage now — Morphine Sulfate, Injection, 10 mg/1 mL (NDC 63323-451-01)Oct 31, 2017
month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
In shortage now — Morphine Sulfate, Injection, 10 mg/1 mL Syringes (NDC 0409-1893-01)Oct 31, 2017
Discontinuation of the manufacture of the drug
month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
In shortage now — Morphine Sulfate, Injection, 10 mg/10 mL (1 mg/mL) (NDC 0409-3815-12)Oct 31, 2017
month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
In shortage now — Morphine Sulfate, Injection, 2 mg/1 mL (NDC 0409-1890-23)Oct 31, 2017
Other
month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
In shortage now — Morphine Sulfate, Injection, 2 mg/1 mL (NDC 63323-452-01)Oct 31, 2017
Other
month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
In shortage now — Morphine Sulfate, Injection, 2 mg/1 mL (NDC 76045-004-11)Oct 31, 2017
Other
month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
In shortage now — Morphine Sulfate, Injection, 2 mg/1 mL Syringes (NDC 0409-1890-01)Oct 31, 2017
month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
In shortage now — Morphine Sulfate, Injection, 4 mg/1 mL (NDC 63323-454-01)Oct 31, 2017
Other
month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
In shortage now — Morphine Sulfate, Injection, 4 mg/1 mL (NDC 76045-005-11)Oct 31, 2017
Other
month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
In shortage now — Morphine Sulfate, Injection, 4 mg/1 mL Syringes (NDC 0409-1891-01)Oct 31, 2017
month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
In shortage now — Morphine Sulfate, Injection, 5 mg/10 mL (0.5 mg/mL) (NDC 0409-3814-12)Oct 31, 2017
month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months
In shortage now — Morphine Sulfate, Injection, 50 mg/1 mL (NDC 0409-1896-20)Oct 31, 2017
Other
month 107 — 5× the typical 20-month injectable shortage · model puts 24% odds it resolves within 6 months

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Morphine Sulfate (Injection, Solution)

Labeler	Strength	First seen	Last seen
Hospira, Inc.	MORPHINE SULFATE 50 mg/mL	Jul 15, 2026	Sep 3, 2026
Bond Pharmacy INC	MORPHINE SULFATE 62.5 mg/mL	Jul 15, 2026	Sep 2, 2026
Fresenius Kabi USA, LLC	MORPHINE SULFATE 4 mg/mL	Jul 15, 2026	Sep 2, 2026
Fresenius Kabi USA, LLC	MORPHINE SULFATE 10 mg/mL	Jul 15, 2026	Sep 2, 2026
Fresenius Kabi USA, LLC	MORPHINE SULFATE 2 mg/mL	Jul 15, 2026	Sep 2, 2026
Fresenius Kabi, USA LLC	MORPHINE SULFATE 4 mg/mL	Jul 15, 2026	Sep 2, 2026
Fresenius Kabi, USA LLC	MORPHINE SULFATE 2 mg/mL	Jul 15, 2026	Sep 2, 2026
Hikma Pharmaceuticals USA Inc.	MORPHINE SULFATE 25 mg/mL	Jul 15, 2026	Sep 2, 2026
Hikma Pharmaceuticals USA Inc.	MORPHINE SULFATE 10 mg/mL	Jul 15, 2026	Sep 2, 2026
Hospira, Inc.	MORPHINE SULFATE 2 mg/mL	Jul 15, 2026	Sep 2, 2026
Hospira, Inc.	MORPHINE SULFATE 1 mg/mL	Jul 15, 2026	Sep 2, 2026
Hospira, Inc.	MORPHINE SULFATE .5 mg/mL	Jul 15, 2026	Sep 2, 2026
Hospira, Inc.	MORPHINE SULFATE 4 mg/mL	Jul 15, 2026	Sep 2, 2026
Hospira, Inc.	MORPHINE SULFATE 10 mg/mL	Jul 15, 2026	Aug 29, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Morphine Sulfate — NDC 76045-0004-11," retrieved September 3, 2026, https://drugdashboards.com/drug/76045000411.

Free to cite with attribution — see how the data is put together.