DrugDashboards

Oxycodone and Acetaminophen

Oxycodone and Acetaminophen · OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 · Tablet · Oral · Rhodes Pharmaceuticals LLC

NDC 42858-0103-01 · 100 TABLET in 1 BOTTLE, PLASTIC · ANDA · View full market →

The short version

16 companies supply this market — deep enough that no single failure threatens the supply. The price is down 13% over the past year, to $0.1825 per unit. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$0.1825per EAinvoice-surveyed acquisition cost · Aug 19, 2026
  • Part D point of sale (median)$0.2440per unitnegotiated price across 5,510 plans — before rebates · Jan 1, 2026
  • Medicaid generic ceiling (FUL)$0.2747per TABweighted avg manufacturer price $0.1569 · Jun 1, 2025151% of what pharmacies pay — higher than 81% of drugs with this benchmark

Medicare Part D

All Part D pricing →
ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$0.2440per unit
middle half $0.1645$0.3289 · 5,510 plans · Jan 1, 2026
Est. net of rebates
≈ $0.2440
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
100%of plans cover it
tier 3 · prior auth 2% · step therapy 0% · qty limit 95%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 4 quarters since 2024.

NADAC price per unit

$0$0.25$0.5$0.75Nov 2014Sep 2026$0.1825
143 price points · per EA · dashed = manufacturer avg (WAMP)Source: CMS NADAC

Estimated fill cost

#30 count
$5.47
#90 count
$16.42

Estimates: latest NADAC unit price × quantity. Pharmacy acquisition cost only — excludes dispensing fees, markup, and insurance terms.

Medicaid spend (2025)

$671,136
39,794 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

0Low risk

Nothing here is signaling trouble: several manufacturers, no current shortage, no recent serious recalls, stable pricing. In drug supply, boring is the good outcome.

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.2%chance of a new FDA shortage posting for oxycodone and acetaminophen (oral solid) in the next 90 days

OAI inspection at a producing facility (24 months) · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier · median tier 3 across plans
  • Costs ≥ $950/fill
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program · Opioid Analgesic REMS Shared System REMS

Regulatory

Application
ANDA201278
TE code
AA
Approval date
Aug 28, 2014
Patents / exclusivity
None on file

Shortage history

  • Planned discontinuation Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 10 mg (NDC 60951-712-70)Nov 3, 2025
  • Planned discontinuation Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 2.5 mg (NDC 60951-701-70)Nov 3, 2025
  • Planned discontinuation Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 5 mg (NDC 60951-602-70)Nov 3, 2025
  • Planned discontinuation Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 5 mg (NDC 60951-602-85)Nov 3, 2025
  • Planned discontinuation Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 7.5 mg (NDC 60951-700-70)Nov 3, 2025

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Oxycodone and Acetaminophen (Tablet)

LabelerStrengthFirst seenLast seen
Asclemed USA, Inc.OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Asclemed USA, Inc.OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Bryant Ranch PrepackOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Bryant Ranch PrepackOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Camber Pharmaceuticals, Inc.OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Camber Pharmaceuticals, Inc.OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Camber Pharmaceuticals, Inc.OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Camber Pharmaceuticals, Inc.OXYCODONE HYDROCHLORIDE 2.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Proficient Rx LPOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Proficient Rx LPOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Alvogen, Inc.OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Alvogen, Inc.OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Alvogen, Inc.OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
American Health PackagingOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
American Health PackagingOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
American Health PackagingOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Amneal Pharmaceuticals LLCOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Amneal Pharmaceuticals of New York LLCOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Amneal Pharmaceuticals of New York LLCOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Asclemed USA, Inc.OXYCODONE HYDROCHLORIDE 2.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Aurolife Pharma, LLCOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Aurolife Pharma, LLCOXYCODONE HYDROCHLORIDE 2.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Aurolife Pharma, LLCOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Aurolife Pharma, LLCOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
AvPAKACETAMINOPHEN 325 mg/1; OXYCODONE HYDROCHLORIDE 10 mg/1Jul 15, 2026Sep 2, 2026
AvPAKOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
AvPAKOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Direct RxOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Direct RxACETAMINOPHEN 325 mg/1; OXYCODONE HYDROCHLORIDE 7.5 mg/1Jul 15, 2026Sep 2, 2026
Direct_RxOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Direct_RxOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Epic Pharma, LLCOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Epic Pharma, LLCOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Epic Pharma, LLCOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Eywa Pharma IncOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Eywa Pharma IncOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Eywa Pharma IncOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
FH2 Pharma LLCOXYCODONE HYDROCHLORIDE 2.5 mg/1; ACETAMINOPHEN 300 mg/1Aug 26, 2026Sep 2, 2026
FH2 Pharma LLCOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 300 mg/1Aug 26, 2026Sep 2, 2026
Forte Bio-Pharma LLCOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 300 mg/1Aug 26, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Oxycodone and Acetaminophen — NDC 42858-0103-01," retrieved September 3, 2026, https://drugdashboards.com/drug/42858010301.

Free to cite with attribution — see how the data is put together.