The short version
16 companies supply this market — deep enough that no single failure threatens the supply.
The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.
Oxycodone And Acetaminophen
oxycodone and acetaminophen · OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 · Tablet · Oral · Bryant Ranch Prepack
NDC 71335-2049-01 · 30 TABLET in 1 BOTTLE · ANDA · View full market →
Medicare Part D
All Part D pricing →Matched to CMS's representative package for this drug (NDC 42858-0104-01) — same generic, strength, and dosage form. CMS prices one NDC per drug concept, not every package.
ⓘ How this was built
Data sources
- CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method
Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.
Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.
Plans pay at point of saleⓘ
$0.2810per unit
middle half $0.1823–$0.3965 · 5,510 plans · Jan 1, 2026
Est. net of rebatesⓘ
≈ $0.2810
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
100%of plans cover it
tier 3 · prior auth 2% · step therapy 0% · qty limit 95%
*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 4 quarters since 2024.
NADAC price per unit
No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.
Supply fragility
Not scored — fragility is computed for NADAC-priced NDCs.
90-day shortage risk (model v2)
0.2%chance of a new FDA shortage posting for oxycodone and acetaminophen (oral solid) in the next 90 days
OAI inspection at a producing facility (24 months) · sole-source market
For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.
Backtested statistical model over the whole market, not this package alone. Model details →
Where it's made
- Bryant Ranch PrepackUnited Statesrelabel · repack
Establishments this product's FDA label declares, located via FDA registration data. How we built this →
Is this a "specialty" drug?
There's no legal definition — it meets 1 of 6 public criteria. Why that matters →
- Part D specialty tier
- Costs ≥ $950/fill
- Biologic (BLA)
- Injectable / infused
- Orphan-drug exclusivity
- REMS program · Opioid Analgesic REMS Shared System REMS
Regulatory
- Application
- ANDA207510
- TE code
- AA
- Approval date
- Mar 21, 2018
- Patents / exclusivity
- None on file
Shortage history
- Planned discontinuation — Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 10 mg (NDC 60951-712-70)Nov 3, 2025
- Planned discontinuation — Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 2.5 mg (NDC 60951-701-70)Nov 3, 2025
- Planned discontinuation — Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 5 mg (NDC 60951-602-70)Nov 3, 2025
- Planned discontinuation — Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 5 mg (NDC 60951-602-85)Nov 3, 2025
- Planned discontinuation — Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 7.5 mg (NDC 60951-700-70)Nov 3, 2025
Recalls (this NDC)
No enforcement reports list this package NDC.
Manufacturers of oxycodone and acetaminophen (Tablet)
| Labeler | Strength | First seen | Last seen |
|---|---|---|---|
| Asclemed USA, Inc. | OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Asclemed USA, Inc. | OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Bryant Ranch Prepack | OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Bryant Ranch Prepack | OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Camber Pharmaceuticals, Inc. | OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Camber Pharmaceuticals, Inc. | OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Camber Pharmaceuticals, Inc. | OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Camber Pharmaceuticals, Inc. | OXYCODONE HYDROCHLORIDE 2.5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Proficient Rx LP | OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Proficient Rx LP | OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 3, 2026 |
| Alvogen, Inc. | OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Alvogen, Inc. | OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Alvogen, Inc. | OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| American Health Packaging | OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| American Health Packaging | OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| American Health Packaging | OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Amneal Pharmaceuticals LLC | OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Amneal Pharmaceuticals of New York LLC | OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Amneal Pharmaceuticals of New York LLC | OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Asclemed USA, Inc. | OXYCODONE HYDROCHLORIDE 2.5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Aurolife Pharma, LLC | OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Aurolife Pharma, LLC | OXYCODONE HYDROCHLORIDE 2.5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Aurolife Pharma, LLC | OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Aurolife Pharma, LLC | OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| AvPAK | ACETAMINOPHEN 325 mg/1; OXYCODONE HYDROCHLORIDE 10 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| AvPAK | OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| AvPAK | OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Direct Rx | OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Direct Rx | ACETAMINOPHEN 325 mg/1; OXYCODONE HYDROCHLORIDE 7.5 mg/1 | Jul 15, 2026 | Sep 2, 2026 |
| Direct_Rx | OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Direct_Rx | OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Epic Pharma, LLC | OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Epic Pharma, LLC | OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Epic Pharma, LLC | OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Eywa Pharma Inc | OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Eywa Pharma Inc | OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Eywa Pharma Inc | OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| FH2 Pharma LLC | OXYCODONE HYDROCHLORIDE 2.5 mg/1; ACETAMINOPHEN 300 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| FH2 Pharma LLC | OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 300 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
| Forte Bio-Pharma LLC | OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 300 mg/1 | Aug 26, 2026 | Sep 2, 2026 |
Roster from daily NDC Directory diffs — first/last seen dates start July 2026.
Cite this page
DrugDashboards, "Oxycodone And Acetaminophen — NDC 71335-2049-01," retrieved September 3, 2026, https://drugdashboards.com/drug/71335204901.
Free to cite with attribution — see how the data is put together.