DrugDashboards

Oxycodone and Acetaminophen

Oxycodone and Acetaminophen · ACETAMINOPHEN 325 mg/1; OXYCODONE HYDROCHLORIDE 10 mg/1 · Tablet · Oral · AvPAK

NDC 50268-0646-15 · 50 BLISTER PACK in 1 BOX / 1 TABLET in 1 BLISTER PACK · ANDA · View full market →

The short version

16 companies supply this market — deep enough that no single failure threatens the supply. The price is down 10% over the past year, to $0.2360 per unit. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$0.2360per EAinvoice-surveyed acquisition cost · Aug 19, 2026
  • Medicaid generic ceiling (FUL)$0.4051per TABweighted avg manufacturer price $0.2315 · Jun 1, 2025172% of what pharmacies pay — higher than 86% of drugs with this benchmark

Medicare Part D

No Medicare Part D plan in CMS's quarterly files lists this product. That usually means it is discontinued, a repackager's listing, or a product no plan has added to its formulary.

How Part D pricing works →

NADAC price per unit

$0$0.2$0.4Dec 2018Sep 2026$0.236
94 price points · per EA · dashed = manufacturer avg (WAMP)Source: CMS NADAC

Estimated fill cost

#30 count
$7.08
#90 count
$21.24

Estimates: latest NADAC unit price × quantity. Pharmacy acquisition cost only — excludes dispensing fees, markup, and insurance terms.

Medicaid spend (2025)

$868
242 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

0● Low risk

Nothing here is signaling trouble: several manufacturers, no current shortage, no recent serious recalls, stable pricing. In drug supply, boring is the good outcome.

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.2%chance of a new FDA shortage posting for oxycodone and acetaminophen (oral solid) in the next 90 days

OAI inspection at a producing facility (24 months) · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier
  • Costs ≥ $950/fill
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program · Opioid Analgesic REMS Shared System REMS

Regulatory

Application
ANDA040778
TE code
AA
Approval date
Nov 27, 2007
Patents / exclusivity
None on file

Shortage history

  • Planned discontinuation — Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 10 mg (NDC 60951-712-70)Nov 3, 2025
  • Planned discontinuation — Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 2.5 mg (NDC 60951-701-70)Nov 3, 2025
  • Planned discontinuation — Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 5 mg (NDC 60951-602-70)Nov 3, 2025
  • Planned discontinuation — Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 5 mg (NDC 60951-602-85)Nov 3, 2025
  • Planned discontinuation — Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 7.5 mg (NDC 60951-700-70)Nov 3, 2025

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Oxycodone and Acetaminophen (Tablet)

LabelerStrengthFirst seenLast seen
Asclemed USA, Inc.OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Asclemed USA, Inc.OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Bryant Ranch PrepackOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Bryant Ranch PrepackOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Camber Pharmaceuticals, Inc.OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Camber Pharmaceuticals, Inc.OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Camber Pharmaceuticals, Inc.OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Camber Pharmaceuticals, Inc.OXYCODONE HYDROCHLORIDE 2.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Proficient Rx LPOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Proficient Rx LPOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 3, 2026
Alvogen, Inc.OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Alvogen, Inc.OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Alvogen, Inc.OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
American Health PackagingOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
American Health PackagingOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
American Health PackagingOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Amneal Pharmaceuticals LLCOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Amneal Pharmaceuticals of New York LLCOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Amneal Pharmaceuticals of New York LLCOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Asclemed USA, Inc.OXYCODONE HYDROCHLORIDE 2.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Aurolife Pharma, LLCOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Aurolife Pharma, LLCOXYCODONE HYDROCHLORIDE 2.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Aurolife Pharma, LLCOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Aurolife Pharma, LLCOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
AvPAKACETAMINOPHEN 325 mg/1; OXYCODONE HYDROCHLORIDE 10 mg/1Jul 15, 2026Sep 2, 2026
AvPAKOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
AvPAKOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Direct RxOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Direct RxACETAMINOPHEN 325 mg/1; OXYCODONE HYDROCHLORIDE 7.5 mg/1Jul 15, 2026Sep 2, 2026
Direct_RxOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Direct_RxOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Epic Pharma, LLCOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Epic Pharma, LLCOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Epic Pharma, LLCOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Eywa Pharma IncOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Eywa Pharma IncOXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
Eywa Pharma IncOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1Aug 26, 2026Sep 2, 2026
FH2 Pharma LLCOXYCODONE HYDROCHLORIDE 2.5 mg/1; ACETAMINOPHEN 300 mg/1Aug 26, 2026Sep 2, 2026
FH2 Pharma LLCOXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 300 mg/1Aug 26, 2026Sep 2, 2026
Forte Bio-Pharma LLCOXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 300 mg/1Aug 26, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Oxycodone and Acetaminophen — NDC 50268-0646-15," retrieved September 3, 2026, https://drugdashboards.com/drug/50268064615.

Free to cite with attribution — see how the data is put together.