DrugDashboards

Carbidopa and Levodopa

Carbidopa and Levodopa · CARBIDOPA 10 mg/1; LEVODOPA 100 mg/1 · Tablet · Oral · Aurobindo Pharma Limited

NDC 59651-0456-01 · 100 TABLET in 1 BOTTLE · ANDA · View full market →

The short version

18 companies supply this market — deep enough that no single failure threatens the supply. The price is down 30% over the past year, to $0.0675 per unit. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$0.0675per EAinvoice-surveyed acquisition cost · Aug 19, 2026
  • Medicaid generic ceiling (FUL)$0.0675per TABweighted avg manufacturer price $0.0358 · Aug 1, 2026100% of what pharmacies pay — higher than 10% of drugs with this benchmark

Medicare Part D

All Part D pricing →

Matched to CMS's representative package for this drug (NDC 78206-0166-01) — same generic, strength, and dosage form. CMS prices one NDC per drug concept, not every package.

ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$1.30per unit
middle half $1.30$1.30 · 2 plans · Apr 1, 2026
Est. net of rebates
≈ $1.30
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
0%of plans cover it
tier 1 · prior auth 0% · step therapy 0% · qty limit 0%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.

NADAC price per unit

$0$0.05$0.1$0.15Aug 2023Sep 2026$0.0675
38 price points · per EA · dashed = manufacturer avg (WAMP)Source: CMS NADAC

Estimated fill cost

#30 count
$2.02
#90 count
$6.07

Estimates: latest NADAC unit price × quantity. Pharmacy acquisition cost only — excludes dispensing fees, markup, and insurance terms.

Medicaid spend (2025)

$5,279
352 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

8Low risk

Some pressure is visible, but not much — here’s everything the score found to count.

  • price down 29% year over year+8

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.1%chance of a new FDA shortage posting for carbidopa and levodopa (oral solid) in the next 90 days

OAI inspection at a producing facility (24 months) · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Regulatory

Application
ANDA216537
TE code
AB
Approval date
Nov 28, 2022
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of Carbidopa and Levodopa (Tablet)

LabelerStrengthFirst seenLast seen
A-S Medication SolutionsCARBIDOPA 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 3, 2026
Aphena Pharma Solutions - Tennessee, LLCCARBIDOPA 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 3, 2026
Bryant Ranch PrepackCARBIDOPA 25 mg/1; LEVODOPA 250 mg/1Jul 15, 2026Sep 3, 2026
Mayne Pharma International Pty LtdLEVODOPA 250 mg/1; CARBIDOPA 25 mg/1Aug 20, 2026Sep 3, 2026
A-S Medication SolutionsCARBIDOPA 10 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Advagen Pharma Ltd.,CARBIDOPA 10 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Advagen Pharma Ltd.,CARBIDOPA 25 mg/1; LEVODOPA 250 mg/1Jul 15, 2026Sep 2, 2026
Advagen Pharma Ltd.,CARBIDOPA 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
American Health PackagingCARBIDOPA 25 mg/1; LEVODOPA 250 mg/1Jul 15, 2026Sep 2, 2026
American Health PackagingCARBIDOPA 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
American Health PackagingCARBIDOPA 10 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Aurobindo Pharma LimitedCARBIDOPA 25 mg/1; LEVODOPA 250 mg/1Jul 15, 2026Sep 2, 2026
Aurobindo Pharma LimitedCARBIDOPA 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Aurobindo Pharma LimitedCARBIDOPA 10 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
AvKARECARBIDOPA 10 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
AvKARECARBIDOPA 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
AvKARECARBIDOPA 25 mg/1; LEVODOPA 250 mg/1Jul 15, 2026Sep 2, 2026
AvPAKCARBIDOPA 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Camber Pharmaceuticals, Inc.CARBIDOPA 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Camber Pharmaceuticals, Inc.CARBIDOPA 25 mg/1; LEVODOPA 250 mg/1Jul 15, 2026Sep 2, 2026
Camber Pharmaceuticals, Inc.CARBIDOPA 10 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Cardinal Health 107, LLCCARBIDOPA HYDRATE 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Cardinal Health 107, LLCCARBIDOPA HYDRATE 25 mg/1; LEVODOPA 250 mg/1Jul 15, 2026Sep 2, 2026
Coupler LLCCARBIDOPA 10 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Coupler LLCCARBIDOPA 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Dr. Reddy's Laboratories IncCARBIDOPA 25 mg/1; LEVODOPA 250 mg/1Jul 15, 2026Sep 2, 2026
Dr. Reddy's Laboratories IncCARBIDOPA 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Dr. Reddy's Laboratories IncCARBIDOPA 10 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Major PharmaceuticalsCARBIDOPA HYDRATE 25 mg/1; LEVODOPA 250 mg/1Jul 15, 2026Sep 2, 2026
Major PharmaceuticalsCARBIDOPA HYDRATE 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Mayne Pharma International Pty LtdCARBIDOPA 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Mayne Pharma International Pty LtdCARBIDOPA 10 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
NCS HealthCare of KY, LLC dba Vangard LabsCARBIDOPA 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
NCS HealthCare of KY, LLC dba Vangard LabsCARBIDOPA 25 mg/1; LEVODOPA 250 mg/1Jul 15, 2026Sep 2, 2026
NCS HealthCare of KY, LLC dba Vangard LabsCARBIDOPA 10 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
NuCare Pharmaceuticals,Inc.CARBIDOPA 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Organon LLCCARBIDOPA 10 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Proficient Rx LPCARBIDOPA 10 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Proficient Rx LPCARBIDOPA 25 mg/1; LEVODOPA 100 mg/1Jul 15, 2026Sep 2, 2026
Proficient Rx LPCARBIDOPA 25 mg/1; LEVODOPA 250 mg/1Jul 15, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Carbidopa and Levodopa — NDC 59651-0456-01," retrieved September 3, 2026, https://drugdashboards.com/drug/59651045601.

Free to cite with attribution — see how the data is put together.