DrugDashboards

Zestoretic

lisinopril and hydrochlorothiazide · LISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1 · Tablet · Oral · Almatica Pharma Inc.

NDC 52427-0437-90 · 90 TABLET in 1 BOTTLE · NDA · View full market →

The short version

16 companies supply this market — deep enough that no single failure threatens the supply.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Part D plans paid (avg)$12.52per dosage unitgross, before rebates — matched by drug name · 2024
  • Part D point of sale (median)$13.01per unitnegotiated price across 2 plans — before rebates · Apr 1, 2026
  • Federal ceiling (Big4)$9.80per unitAlmatica LLC. · Jan 1, 2026
  • Medicaid generic ceiling (FUL)$0.0405per TABweighted avg manufacturer price $0.0174 · Aug 1, 2026

Medicare Part D

All Part D pricing →
ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$13.01per unit
middle half $13.01$13.01 · 2 plans · Apr 1, 2026
Est. net of rebates
$7.81–$9.76
brand drug — est. 25-40% rebate off the price at left
Coverage & restrictions
0%of plans cover it
tier 1 · prior auth 0% · step therapy 0% · qty limit 0%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.

NADAC price per unit

No NADAC pricing on file for this NDC — NADAC covers drugs dispensed by retail community pharmacies.

Estimated fill cost

WAC per package, as filed
$1,196.32
Reported to Texas DSHS · 2026 annual filing · Almatica Pharma, Llc.

Manufacturer list price as filed — not what pharmacies actually pay after discounts.

Supply fragility

Not scored — fragility is computed for NADAC-priced NDCs.

90-day shortage risk (model v2)

0.2%chance of a new FDA shortage posting for lisinopril and hydrochlorothiazide (oral solid) in the next 90 days

OAI inspection at a producing facility (24 months) · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Is this a "specialty" drug?

There's no legal definition — it meets 1 of 6 public criteria. Why that matters →

  • Part D specialty tier · median tier 1 across plans
  • Costs ≥ $950/fill · avg $1,056.67 per prescription
  • Biologic (BLA)
  • Injectable / infused
  • Orphan-drug exclusivity
  • REMS program

Regulatory

Application
NDA019888
TE code
AB
Approval date
Jul 20, 1989
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

No enforcement reports list this package NDC.

Manufacturers of lisinopril and hydrochlorothiazide (Tablet)

LabelerStrengthFirst seenLast seen
Actavis Pharma, Inc.LISINOPRIL 10 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 20, 2026Sep 3, 2026
Actavis Pharma, Inc.LISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 20, 2026Sep 3, 2026
Actavis Pharma, Inc.LISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 20, 2026Sep 3, 2026
Aurobindo Pharma LimitedLISINOPRIL 10 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 20, 2026Sep 3, 2026
Aurobindo Pharma LimitedLISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 20, 2026Sep 3, 2026
Aurobindo Pharma LimitedLISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 20, 2026Sep 3, 2026
Advanced Rx Pharmacy of Tennessee, LLCHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026
Almatica Pharma Inc.LISINOPRIL 10 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
Almatica Pharma Inc.LISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 26, 2026Sep 2, 2026
Almatica Pharma Inc.LISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
Aphena Pharma Solutions - Tennessee, LLCLISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
Bryant Ranch PrepackHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Bryant Ranch PrepackHYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Bryant Ranch PrepackLISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
Bryant Ranch PrepackHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026
Coupler LLCHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
GSMS, IncorporatedLISINOPRIL 10 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
GSMS, IncorporatedLISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 26, 2026Sep 2, 2026
GSMS, IncorporatedLISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
Legacy Pharmaceutical Packaging, LLCHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Legacy Pharmaceutical Packaging, LLCHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026
Legacy Pharmaceutical Packaging, LLCHYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Lupin Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Lupin Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026
Lupin Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Northwind Health Company, LLCHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Northwind Health Company, LLCHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026
Northwind Health Company, LLCHYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Northwind Health Company, LLCLISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
NuCare Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
NuCare Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
NuCare Pharmaceuticals,Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026
NuCare Pharmaceuticals,Inc.LISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
NuCarePharmaceuticals, Inc.LISINOPRIL 10 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
PD-Rx Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026
PD-Rx Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
PD-Rx Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Preferred Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Preferred Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Preferred Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Zestoretic — NDC 52427-0437-90," retrieved September 3, 2026, https://drugdashboards.com/drug/52427043790.

Free to cite with attribution — see how the data is put together.