DrugDashboards

Lisinopril and Hydrochlorothiazide

Lisinopril and Hydrochlorothiazide · HYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1 · Tablet · Oral · Lupin Pharmaceuticals, Inc.

NDC 68180-0520-01 · 100 TABLET in 1 BOTTLE · ANDA · View full market →

The short version

16 companies supply this market — deep enough that no single failure threatens the supply. The price has held steady around $0.0405 per unit over the past year. One of its named manufacturing plants, Lupin Limited, failed FDA inspectionwithin the last two years — the agency’s most serious outcome. Put together: this looks like a healthy supply — the boring kind, which is exactly what you want.

The numbers behind every sentence are on this page below — and the Watch button emails you when any of them move.

One drug, every price

The same NDC has different prices depending on who is paying. Units differ between rungs — compare within a rung over time, not rung against rung, unless the units match.

ⓘ How this was built
Data sources
  • CMS NADAC (pharmacy acquisition, weekly)
  • CMS Part B ASP quarterly payment limits
  • CMS Maximum Fair Prices (IRA negotiated, NDC-level)
  • Medicare Part D Spending by Drug (data.cms.gov, name-matched)
  • VA FSS / Big4 federal contract prices (va.gov, twice monthly)
  • ACA Federal Upper Limits + weighted AMP (data.medicaid.gov, monthly)
  • California SB-17 WAC filings (list price, per package)
Method

Each rung is the newest figure for this NDC from one federal price system, shown with its own unit. Part D is matched by drug name because CMS publishes no NDCs there; it is gross spending, before confidential rebates.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

  • Pharmacies pay (NADAC)$0.0405per EAinvoice-surveyed acquisition cost · Aug 19, 2026
  • Medicaid generic ceiling (FUL)$0.0405per TABweighted avg manufacturer price $0.0174 · Aug 1, 2026100% of what pharmacies pay — higher than 10% of drugs with this benchmark

Medicare Part D

All Part D pricing →

Matched to CMS's representative package for this drug (NDC 68180-0520-02) — same generic, strength, and dosage form. CMS prices one NDC per drug concept, not every package.

ⓘ How this was built
Data sources
  • CMS quarterly Prescription Drug Plan Formulary & Pricing files (SPUF)
Method

Negotiated 30-day point-of-sale unit prices and formulary terms aggregated across every unsuppressed Part D and MA-PD plan for the quarter shown. Point of sale means gross of confidential rebates. CMS publishes one representative NDC per drug concept (RxCUI) rather than every package, so these figures come from CMS's representative package for the same drug — matched on generic name, strength, and dosage form. Estimated from MedPAC's program-wide rebate aggregates (June 2023: DIR = 29% of gross Part D spending; brand rebates ≈ 25–40% of gross, generics minimal). Actual rebates are confidential and vary widely by drug — this is a range, not a fact about this drug.

Pipeline and calculations built by Claude (Fable 5) from the public datasets above. Educational only — verify against primary sources before acting.

Plans pay at point of sale
$0.1198per unit
middle half $0.0780$0.1687 · 5,496 plans · Apr 1, 2026
Est. net of rebates
≈ $0.1198
generic — rebates are minimal, so net ≈ gross
Coverage & restrictions
100%of plans cover it
tier 1 · prior auth 0% · step therapy 0% · qty limit 23%

*No drug-level rebate is public — the estimate applies MedPAC's program-wide brand rebate range to this drug's gross price. Tracked here for 10 quarters since 2024.

NADAC price per unit

$0$0.05$0.1$0.15Nov 2013Sep 2026$0.0405
155 price points · per EA · dashed = manufacturer avg (WAMP)Source: CMS NADAC

Estimated fill cost

#30 count
$1.21
#90 count
$3.64

Estimates: latest NADAC unit price × quantity. Pharmacy acquisition cost only — excludes dispensing fees, markup, and insurance terms.

Medicaid spend (2025)

$838,941
94,194 prescriptions paid by Medicaid nationally · all Medicaid spend →

Supply fragility

0Low risk

Nothing here is signaling trouble: several manufacturers, no current shortage, no recent serious recalls, stable pricing. In drug supply, boring is the good outcome.

The score counts pressure that is already visible — fewer makers, shortages, recalls, falling prices. 0 means none of it; 100 means all of it at once. Recomputed daily · as of Sep 3, 2026

90-day shortage risk (model v2)

0.2%chance of a new FDA shortage posting for lisinopril and hydrochlorothiazide (oral solid) in the next 90 days

OAI inspection at a producing facility (24 months) · sole-source market

For scale: the typical drug’s chance is about 0.1% — this one is in ordinary territory.

Backtested statistical model over the whole market, not this package alone. Model details →

Where it's made

Establishments this product's FDA label declares, located via FDA registration data. How we built this →

Regulatory

Application
ANDA077912
TE code
AB
Approval date
Sep 27, 2006
Patents / exclusivity
None on file

Shortage history

No FDA shortage reports for this drug or its presentations.

Recalls (this NDC)

  • Class II · OngoingJun 20, 2025
    Lupin Pharmaceuticals Inc.Product Mix Up: This product is being recalled because of a complaint received that a sealed bottle of lisinopril and hydrochlorothiazide tablets 20mg/12.5 mg had a foreign tablet identified as atazanavir and ritonavir tablet 300mg/100mg.
  • Class II · TerminatedJan 26, 2022
    CARDINAL HEALTHCARECGMP Deviations: Products were exposed to temperatures outside of the products labeled storage conditions.
  • Class II · TerminatedJul 19, 2019
    Lupin Pharmaceuticals Inc.Presence of Foreign Tablets/Capsules: Product complaint received of one Fenofibrate tablet 145mg observed in 500 s count product bottle.
  • Class II · TerminatedJul 17, 2019
    Lupin Pharmaceuticals Inc.Presence of Foreign Substance; Product complaints received related to brownish/blackish stains on the tablets and brownish/blackish powder observed inside the bottles.
  • Class III · TerminatedApr 4, 2016
    Lupin Pharmaceuticals Inc.CGMP Deviations: finished products manufactured using active pharmaceutical ingredients whose intermediates failed specifications.

Manufacturers of Lisinopril and Hydrochlorothiazide (Tablet)

LabelerStrengthFirst seenLast seen
Actavis Pharma, Inc.LISINOPRIL 10 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 20, 2026Sep 3, 2026
Actavis Pharma, Inc.LISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 20, 2026Sep 3, 2026
Actavis Pharma, Inc.LISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 20, 2026Sep 3, 2026
Aurobindo Pharma LimitedLISINOPRIL 10 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 20, 2026Sep 3, 2026
Aurobindo Pharma LimitedLISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 20, 2026Sep 3, 2026
Aurobindo Pharma LimitedLISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 20, 2026Sep 3, 2026
Advanced Rx Pharmacy of Tennessee, LLCHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026
Almatica Pharma Inc.LISINOPRIL 10 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
Almatica Pharma Inc.LISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 26, 2026Sep 2, 2026
Almatica Pharma Inc.LISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
Aphena Pharma Solutions - Tennessee, LLCLISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
Bryant Ranch PrepackHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Bryant Ranch PrepackHYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Bryant Ranch PrepackLISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
Bryant Ranch PrepackHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026
Coupler LLCHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
GSMS, IncorporatedLISINOPRIL 10 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
GSMS, IncorporatedLISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 25 mg/1Aug 26, 2026Sep 2, 2026
GSMS, IncorporatedLISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
Legacy Pharmaceutical Packaging, LLCHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Legacy Pharmaceutical Packaging, LLCHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026
Legacy Pharmaceutical Packaging, LLCHYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Lupin Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Lupin Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026
Lupin Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Northwind Health Company, LLCHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Northwind Health Company, LLCHYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026
Northwind Health Company, LLCHYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Northwind Health Company, LLCLISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
NuCare Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
NuCare Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
NuCare Pharmaceuticals,Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026
NuCare Pharmaceuticals,Inc.LISINOPRIL 20 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
NuCarePharmaceuticals, Inc.LISINOPRIL 10 mg/1; HYDROCHLOROTHIAZIDE 12.5 mg/1Aug 26, 2026Sep 2, 2026
PD-Rx Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026
PD-Rx Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
PD-Rx Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Preferred Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 25 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Preferred Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 20 mg/1Jul 15, 2026Sep 2, 2026
Preferred Pharmaceuticals, Inc.HYDROCHLOROTHIAZIDE 12.5 mg/1; LISINOPRIL 10 mg/1Jul 15, 2026Sep 2, 2026

Roster from daily NDC Directory diffs — first/last seen dates start July 2026.

Cite this page

DrugDashboards, "Lisinopril and Hydrochlorothiazide — NDC 68180-0520-01," retrieved September 3, 2026, https://drugdashboards.com/drug/68180052001.

Free to cite with attribution — see how the data is put together.